Anaplastic Large Cell Lymphoma: Contemporary Concepts and Optimal Management.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer treatment and research"
DOI: 10.1007/978-3-319-99716-2_6
Abstract: Anaplastic Large Cell Lymphomas (ALCL) are clinically aggressive and pathologically distinct lymphoid neoplasms that originate from a mature post-thymic T-cell. The contemporary World Health Organization (WHO) Classification of Haematologic Malignancies recognizes two distinct subtypes of… read more here.
Keywords: alcl; alk positive; management; large cell ... See more keywords
A novel model of alternative NF-κB pathway activation in anaplastic large cell lymphoma
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-01088-y
Abstract: Aberrant activation of NF-κB is the most striking oncogenic mechanism in B-cell lymphoma; however, its role in anaplastic large cell lymphomas (ALCL) has not been fully established and its activation mechanism(s) remain unclear. Using ALCL… read more here.
Keywords: alk; alcl; pathway; activation ... See more keywords
How I Diagnose Anaplastic Large Cell Lymphoma.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqab012
Abstract: OBJECTIVES This review describes our approach to the diagnosis of all 4 anaplastic large cell lymphoma (ALCL) entities. METHODS ALCLs are a group of CD30-positive mature T-cell lymphomas with similar morphologic and phenotypic characteristics but… read more here.
Keywords: alcl; large cell; cell; anaplastic large ... See more keywords
Anaplastic Large Cell Lymphoma Manifesting as Pleural Effusion in a Patient with Long-Standing Eosinophilia.
Sign Up to like & getrecommendations! Published in 2019 at "Laboratory medicine"
DOI: 10.1093/labmed/lmy035
Abstract: Anaplastic large cell lymphoma (ALCL) is a lymphoma of T-cell origin, characterized by the presence of large lymphoid cells with abundant cytoplasm and pleomorphic, often horseshoe-shaped nuclei (hallmark cells), as well as strong and uniform… read more here.
Keywords: lymphoma; alcl; large cell; cell ... See more keywords
How to Diagnose Anaplastic Large Cell Lymphoma on Cytological Samples? A Series with Emphasis on Diagnostic Clue and Pitfalls.
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DOI: 10.1159/000528533
Abstract: INTRODUCTION Anaplastic large cell lymphoma (ALCL) is a rare mature T-cell non-Hodgkin's lymphoma characterized by large and pleomorphic neoplastic CD30-positive T cells. ALCL includes different subtypes with different clinical and biological features: systemic ALCL, primary… read more here.
Keywords: cell; diagnosis; cytological samples; alcl ... See more keywords
MYC Expression in Systemic Anaplastic Large Cell Lymphoma: Clinicopathologic and Prognostic Features of 70 Patients
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-124556
Abstract: Background: Dysregulation of MYC has oncogenic potential. It has been reported that MYC dysregulation (gene rearrangement, increased copy number, and protein overexpression) predicts poorer prognosis in patients with diffuse large B cell lymphoma. Systemic anaplastic… read more here.
Keywords: alcl; expression; alk negative; myc expression ... See more keywords
GSK1838705a, an IGF-1R/ALK Inhibitor, Overcomes Resistance to Crizotinib in ALK-Positive ALCL
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-130063
Abstract: Anaplastic large cell lymphoma (ALCL) is a type of CD30-expressing non-Hodgkin's lymphoma (NHL), which accounts for 2% to 3% of adult non-Hodgkin's lymphoma,accounting for 15% to 30% of children with large cell lymphoma. Anaplastic lymphoma… read more here.
Keywords: crizotinib resistant; alk; alcl; alk alcl ... See more keywords
GATA3 Gene - a Potential New Biomarker Associated with Adverse Outcomes in ALK1-Negative Anaplastic Large Cell Lymphoma: Preliminary Results from a Retrospective Cohort of 80 South American Cases of Nodal Peripheral T Lymphoma
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DOI: 10.1182/blood-2020-140833
Abstract: Introduction: Nodal peripheral T-cell lymphomas (nPTCLs) comprise a heterogeneous group of mature and aggressive T-cell lymphoid malignancies, including peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS), angioimmunoblastic T-cell lymphoma (AITL) and anaplastic large cell lymphomas… read more here.
Keywords: alcl; gata3 gene; gene; cell ... See more keywords
Metagenomic analysis to identify novel infectious agents in systemic anaplastic large cell lymphoma
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DOI: 10.1186/s13027-021-00404-0
Abstract: Systemic anaplastic large cell lymphoma (ALCL) is a rare CD30-expressing T-cell non-Hodgkin lymphoma. Risk of systemic ALCL is highly increased among immunosuppressed individuals. Because risk of cancers associated with viruses is increased with immunosuppression, we… read more here.
Keywords: lymphoma; alcl; analysis; systemic anaplastic ... See more keywords
DUSP22 rearrangement is associated with a distinctive immunophenotype but not outcome in patients with systemic ALK-negative anaplastic large cell lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2022.281222
Abstract: DUSP22 rearrangement (R) has been associated with a favorable outcome in systemic ALK-negative anaplastic large cell lymphoma (ALCL). However, a recent study found that patients with DUSP22-R ALK-negative ALCL have a poorer prognosis than was… read more here.
Keywords: alk negative; rearrangement; alcl; patients dusp22 ... See more keywords
Regulation of CD45 phosphatase by oncogenic ALK in anaplastic large cell lymphoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1085672
Abstract: Anaplastic Large Cell Lymphoma (ALCL) is a subtype of non-Hodgkin lymphoma frequently driven by the chimeric tyrosine kinase NPM-ALK, generated by the t (2,5)(p23;q35) translocation. While ALK+ ALCL belongs to mature T cell lymphomas, loss… read more here.
Keywords: cell; npm alk; expression; cd45 ... See more keywords