An Open‐Label, Dose‐Escalation Study to Assess the Safety and Efficacy of IL‐22 Agonist F‐652 in Patients With Alcohol‐associated Hepatitis
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DOI: 10.1002/hep.31046
Abstract: Interleukin‐22 has beneficial effects on inflammation and impaired hepatic regeneration that characterize alcohol‐associated hepatitis (AH). F‐652 is a recombinant fusion protein of human interleukin‐22 and immunoglobulin G2 fragment crystallizable. This study aims to assess the… read more here.
Keywords: associated hepatitis; alcohol associated; safety efficacy; 652 patients ... See more keywords
Reducing the Global Burden of Alcohol‐Associated Liver Disease: A Blueprint for Action
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DOI: 10.1002/hep.31583
Abstract: Alcohol‐associated liver disease (ALD) is a major driver of global liver related morbidity and mortality. There are 2.4 billion drinkers (950 million heavy drinkers) and the lifetime prevalence of any alcohol use disorder (AUD) is… read more here.
Keywords: alcohol associated; associated liver; global burden; liver disease ... See more keywords
IL-1 receptor antagonist plus pentoxifylline and zinc for severe alcohol-associated hepatitis.
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DOI: 10.1002/hep.32478
Abstract: BACKGROUND & AIMS Patients with severe alcohol-associated hepatitis (AH) have high mortality. Corticosteroids improve survival only for 30 days. We targeted inflammation, cellular injury and gut leakiness in a randomized clinical trial comparing combination therapy… read more here.
Keywords: survival; alcohol associated; associated hepatitis; severe alcohol ... See more keywords
Transplants for Acute Alcoholic Hepatitis: Controversies and Early Successes.
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DOI: 10.1016/j.cld.2020.08.010
Abstract: Liver transplant for severe alcohol-associated hepatitis remains a controversial practice despite evidence for a substantial survival benefit compared with medical therapy and posttransplant alcohol relapse rates comparable with previously published studies in alcohol-associated cirrhosis. The… read more here.
Keywords: alcohol associated; hepatitis; transplants acute; hepatitis controversies ... See more keywords
Malnutrition and Alcohol-Associated Hepatitis.
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DOI: 10.1016/j.cld.2021.03.002
Abstract: Malnutrition is common in alcohol-associated hepatitis (AH); almost all patients with severe AH have some component of malnutrition. The classic phenotype of malnutrition in AH is sarcopenia, but this has become more difficult to discern… read more here.
Keywords: associated hepatitis; alcohol associated; malnutrition; alcohol ... See more keywords
Current Therapies for Alcohol-Associated Hepatitis.
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DOI: 10.1016/j.cld.2021.03.005
Abstract: Alcohol-associated hepatitis is associated with poor outcomes, especially when severe. Despite extensive study with a plethora of potential therapeutic agents, treatment options remain limited, with the current standard of therapy being corticosteroids. Granulocyte colony-stimulating factor… read more here.
Keywords: current therapies; associated hepatitis; alcohol associated; therapies alcohol ... See more keywords
Alcohol-associated cancer and deregulation of Pol III genes.
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DOI: 10.1016/j.gene.2016.09.046
Abstract: Emerging evidence indicates that alcohol intake is associated with human cancers in different organs. However, the molecular mechanism of alcohol-associated human cancers remains to be elucidated. Here, this paper aimed to clarify a novel mechanism… read more here.
Keywords: pol iii; associated cancer; cancer deregulation; alcohol associated ... See more keywords
Alcohol-associated liver disease: A review on its pathophysiology, diagnosis and drug therapy
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DOI: 10.1016/j.toxrep.2021.02.010
Abstract: Highlights • Chronic intake of alcohol initiates a pathogenic process that involves the production of protein-aldehyde adducts, and release of cytokines.• Involved gene polymorphisms may include alcohol dehydrogenase, cytochrome P4502E1, and those associated with alcoholism.•… read more here.
Keywords: alcohol associated; associated liver; disease review; review pathophysiology ... See more keywords
NATURAL HISTORY OF ALCOHOL-ASSOCIATED LIVER DISEASE: UNDERSTANDING THE CHANGING LANDSCAPE OF PATHOPHYSIOLOGY AND PATIENT CARE.
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DOI: 10.1053/j.gastro.2022.05.031
Abstract: Alcohol and consequent liver disease are a major burden, which has worsened during the COVID-19 pandemic. There are several facets to the pathophysiology and clinical consequences of alcohol-use disorder (AUD) and progression to alcohol-associated liver… read more here.
Keywords: natural history; associated liver; alcohol associated; history alcohol ... See more keywords
Inflammation in alcohol-associated liver disease progression.
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DOI: 10.1055/a-1714-9246
Abstract: Chronic alcohol consumption induces stress and damage in alcohol metabolising hepatocytes, which leads to inflammatory and fibrogenic responses. Besides these direct effects, alcohol disrupts intestinal barrier functions and induces gut microbial dysbiosis, causing translocation of… read more here.
Keywords: alcohol associated; liver disease; alcohol; associated liver ... See more keywords
The Changing Epidemiology of ALD: Sex, Race, and Risk Factors.
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DOI: 10.1055/a-2000-6680
Abstract: Cases of alcohol-associated liver disease (ALD) are increasing at a steady rate in the United States with more patients presenting with alcohol-associated hepatitis (AH) and alcohol-associated cirrhosis (AC). While alcohol use has increased across many… read more here.
Keywords: race; alcohol associated; risk; alcohol ... See more keywords