Postbiotics From Lactobacillus Johnsonii Activates Gut Innate Immunity to Mitigate Alcohol‐Associated Liver Disease
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DOI: 10.1002/advs.202405781
Abstract: Prolonged alcohol consumption disrupts the gut microbiota and the immune system, contributing to the pathogenesis of alcohol‐associated liver disease (ALD). Probiotic‐postbiotic intervention strategies can effectively relieve ALD by maintaining gut homeostasis. Herein, the efficacy of… read more here.
Keywords: lactobacillus johnsonii; associated liver; alcohol associated; johnsonii ... See more keywords
An Open‐Label, Dose‐Escalation Study to Assess the Safety and Efficacy of IL‐22 Agonist F‐652 in Patients With Alcohol‐associated Hepatitis
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DOI: 10.1002/hep.31046
Abstract: Interleukin‐22 has beneficial effects on inflammation and impaired hepatic regeneration that characterize alcohol‐associated hepatitis (AH). F‐652 is a recombinant fusion protein of human interleukin‐22 and immunoglobulin G2 fragment crystallizable. This study aims to assess the… read more here.
Keywords: associated hepatitis; alcohol associated; safety efficacy; 652 patients ... See more keywords
Reducing the Global Burden of Alcohol‐Associated Liver Disease: A Blueprint for Action
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DOI: 10.1002/hep.31583
Abstract: Alcohol‐associated liver disease (ALD) is a major driver of global liver related morbidity and mortality. There are 2.4 billion drinkers (950 million heavy drinkers) and the lifetime prevalence of any alcohol use disorder (AUD) is… read more here.
Keywords: alcohol associated; associated liver; global burden; liver disease ... See more keywords
IL-1 receptor antagonist plus pentoxifylline and zinc for severe alcohol-associated hepatitis.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32478
Abstract: BACKGROUND & AIMS Patients with severe alcohol-associated hepatitis (AH) have high mortality. Corticosteroids improve survival only for 30 days. We targeted inflammation, cellular injury and gut leakiness in a randomized clinical trial comparing combination therapy… read more here.
Keywords: survival; alcohol associated; associated hepatitis; severe alcohol ... See more keywords
Transplants for Acute Alcoholic Hepatitis: Controversies and Early Successes.
Sign Up to like & getrecommendations! Published in 2021 at "Clinics in liver disease"
DOI: 10.1016/j.cld.2020.08.010
Abstract: Liver transplant for severe alcohol-associated hepatitis remains a controversial practice despite evidence for a substantial survival benefit compared with medical therapy and posttransplant alcohol relapse rates comparable with previously published studies in alcohol-associated cirrhosis. The… read more here.
Keywords: alcohol associated; hepatitis; transplants acute; hepatitis controversies ... See more keywords
Malnutrition and Alcohol-Associated Hepatitis.
Sign Up to like & getrecommendations! Published in 2021 at "Clinics in liver disease"
DOI: 10.1016/j.cld.2021.03.002
Abstract: Malnutrition is common in alcohol-associated hepatitis (AH); almost all patients with severe AH have some component of malnutrition. The classic phenotype of malnutrition in AH is sarcopenia, but this has become more difficult to discern… read more here.
Keywords: associated hepatitis; alcohol associated; malnutrition; alcohol ... See more keywords
Current Therapies for Alcohol-Associated Hepatitis.
Sign Up to like & getrecommendations! Published in 2021 at "Clinics in liver disease"
DOI: 10.1016/j.cld.2021.03.005
Abstract: Alcohol-associated hepatitis is associated with poor outcomes, especially when severe. Despite extensive study with a plethora of potential therapeutic agents, treatment options remain limited, with the current standard of therapy being corticosteroids. Granulocyte colony-stimulating factor… read more here.
Keywords: current therapies; associated hepatitis; alcohol associated; therapies alcohol ... See more keywords
Alcohol-associated cancer and deregulation of Pol III genes.
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DOI: 10.1016/j.gene.2016.09.046
Abstract: Emerging evidence indicates that alcohol intake is associated with human cancers in different organs. However, the molecular mechanism of alcohol-associated human cancers remains to be elucidated. Here, this paper aimed to clarify a novel mechanism… read more here.
Keywords: pol iii; associated cancer; cancer deregulation; alcohol associated ... See more keywords
Alcohol-associated liver disease: A review on its pathophysiology, diagnosis and drug therapy
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DOI: 10.1016/j.toxrep.2021.02.010
Abstract: Highlights • Chronic intake of alcohol initiates a pathogenic process that involves the production of protein-aldehyde adducts, and release of cytokines.• Involved gene polymorphisms may include alcohol dehydrogenase, cytochrome P4502E1, and those associated with alcoholism.•… read more here.
Keywords: alcohol associated; associated liver; disease review; review pathophysiology ... See more keywords
Minibioreactor arrays to model microbiome response to alcohol and tryptophan in the context of alcohol-associated liver disease
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DOI: 10.1038/s41522-024-00602-9
Abstract: The intestinal microbiota (IM) plays a role in the severity of alcohol-associated liver disease. Modifying severe alcohol-associated hepatitis (AH) dysbiosis improves liver injury through tryptophan (Trp) metabolites and the aryl hydrocarbon receptor (AhR). However, Trp’s… read more here.
Keywords: minibioreactor arrays; associated liver; alcohol associated; trp ... See more keywords
NATURAL HISTORY OF ALCOHOL-ASSOCIATED LIVER DISEASE: UNDERSTANDING THE CHANGING LANDSCAPE OF PATHOPHYSIOLOGY AND PATIENT CARE.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.05.031
Abstract: Alcohol and consequent liver disease are a major burden, which has worsened during the COVID-19 pandemic. There are several facets to the pathophysiology and clinical consequences of alcohol-use disorder (AUD) and progression to alcohol-associated liver… read more here.
Keywords: natural history; associated liver; alcohol associated; history alcohol ... See more keywords