Acute drug effects on habitual and non-habitual responding in crossed high alcohol preferring mice
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4914-8
Abstract: RationaleDrug reward plays a central role in acquiring drug-seeking behavior. However, subjects may continue using drugs despite negative consequences because self-administration becomes habitual, and divorced from outcome values. Although a history of drug and alcohol… read more here.
Keywords: high alcohol; crossed high; drug; habitual responding ... See more keywords
Alcohol and Cocaine Exposure Modulates ABCB1 and ABCG2 Transporters in Male Alcohol-Preferring Rats
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1153-2
Abstract: Two efflux transporters, ATP-binding cassettes B1 (ABCB1) and G2 (ABCG2), are highly expressed in the endothelial cells of the brain, where they regulate the bioavailability and distribution of several endogenous and xenobiotic compounds. However, whether… read more here.
Keywords: cocaine; alcohol preferring; abcb1 abcg2; male alcohol ... See more keywords
Differential COMT expression and behavioral effects of COMT inhibition in male and female Wistar and alcohol preferring rats.
Sign Up to like & getrecommendations! Published in 2018 at "Alcohol"
DOI: 10.1016/j.alcohol.2017.08.007
Abstract: Polymorphisms of the catechol-O-methyl transferase (COMT) gene have been associated with alcoholism, suggesting that alterations in the metabolism of catecholamines may be a critical component of the neuropathology of alcoholism. In the current experiments, the… read more here.
Keywords: male female; comt expression; expression; wistar ... See more keywords
Genetically selected alcohol-preferring msP rats to study alcohol use disorder: Anything lost in translation?
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DOI: 10.1016/j.neuropharm.2020.108446
Abstract: For several decades, genetically selected alcohol-preferring rats have been successfully used to mimic and study alcohol use disorders (AUD). These rat lines have been instrumental in advancing our understanding of the neurobiology of alcoholism and… read more here.
Keywords: selected alcohol; msp rats; genetically selected; alcohol preferring ... See more keywords
Chronic Ethanol Consumption Alters Glucocorticoid Receptor Isoform Expression in Stress Neurocircuits and Mesocorticolimbic Brain Regions of Alcohol-Preferring Rats
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DOI: 10.1016/j.neuroscience.2020.04.033
Abstract: Evidence suggests the hypothalamic-pituitary-adrenal (HPA) axis is involved in Alcohol Use Disorders (AUDs), which might be mediated by an imbalance of glucocorticoid receptor (GR), GRα and GRβ, activity. GRβ antagonizes the GRα isoform to cause… read more here.
Keywords: isoform expression; ethanol drinking; expression; alcohol preferring ... See more keywords
Sub-dimensions of Alcohol Use Disorder in Alcohol Preferring and Non-preferring Rats, a Comparative Study
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2019.00003
Abstract: Recent animal models of alcohol use disorder (AUD) are centered in capturing individual vulnerability differences in disease progression. Here, we used genetically selected Marchigian Sardinian alcohol-preferring (msP) and Wistars rats to apply a multidimensional model… read more here.
Keywords: msp rats; non preferring; alcohol preferring; alcohol ... See more keywords