Targeted overexpression of CRH receptor subtype 1 in central amygdala neurons: effect on alcohol-seeking behavior
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4908-6
Abstract: RationaleThe corticotropin-releasing hormone (CRH) system is a key mediator of stress-induced responses in alcohol-seeking behavior. Recent research has identified the central nucleus of the amygdala (CeA), a brain region involved in the regulation of fear… read more here.
Keywords: cea; crhr1; effect; crh ... See more keywords
Individual differences in social play behaviour predict alcohol intake and control over alcohol seeking in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05929-1
Abstract: RATIONALE Social play behaviour is a rewarding social activity displayed by young mammals, thought to be important for the development of brain and behaviour. Indeed, disruptions of social play behaviour in rodents have been associated… read more here.
Keywords: alcohol intake; social play; control; play behaviour ... See more keywords
Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2018.01.026
Abstract: BACKGOUND Alcohol use disorder (AUD) is devastating and poorly treated, and innovative targets are actively sought for prevention and treatment. The orphan G protein-coupled receptor GPR88 is enriched in mesocorticolimbic pathways, and Gpr88 knockout mice… read more here.
Keywords: connectivity; alcohol; knockout mice; mice ... See more keywords
Gut microbiome correlates with altered striatal dopamine receptor expression in a model of compulsive alcohol seeking
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.08.026
Abstract: ABSTRACT Identifying biological markers predicting vulnerability to develop excessive alcohol consumption may lead to a real improvement of clinical care. With converging evidence suggesting that gut microbiome is capable of influencing brain and behavior, this… read more here.
Keywords: dopamine receptor; alcohol seeking; alcohol; gut microbiome ... See more keywords
Optogenetic control of alcohol-seeking behavior via the dorsomedial striatal circuit
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.05.022
Abstract: Alcohol consumption alters glutamatergic transmission in many brain regions, including the dorsomedial striatum (DMS); this aberrant plasticity is thought to be responsible for alcohol-seeking behavior. Recent studies reported that alcohol induced such plasticity specifically in… read more here.
Keywords: self administration; seeking behavior; operant alcohol; alcohol self ... See more keywords
Differential Roles for L-Type Calcium Channel Subtypes in Alcohol Dependence
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DOI: 10.1038/npp.2016.266
Abstract: It has previously been shown that the inhibition of L-type calcium channels (LTCCs) decreases alcohol consumption, although the contribution of the central LTCC subtypes Cav1.2 and Cav1.3 remains unknown. Here, we determined changes in Cav1.2… read more here.
Keywords: dependence; type calcium; cav1; calcium ... See more keywords
The GABAB Positive Allosteric Modulator ADX71441 Attenuates Alcohol Self-Administration and Relapse to Alcohol Seeking in Rats
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2017.53
Abstract: GABAergic signaling is involved in modulating the reinforcing properties of alcohol, and GABAB receptors have been proposed as a potential target for clinical treatment of alcoholism. The orthosteric GABAB receptor agonist baclofen has been shown… read more here.
Keywords: self administration; allosteric modulator; relapse; alcohol seeking ... See more keywords
The ventral pallidum and relapse in alcohol seeking
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15160
Abstract: Alcohol‐use disorders are chronically relapsing conditions characterized by cycles of use, abstinence and relapse. The ventral pallidum (VP) is a key node in the neural circuits controlling relapse to alcohol seeking and a key target… read more here.
Keywords: relapse alcohol; relapse; alcohol seeking; alcohol ... See more keywords
Compulsive alcohol seeking and relapse: Central role of conditioning factors associated with alleviation of withdrawal states by alcohol
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15854
Abstract: Learned associations between environmental stimuli and drugs of abuse represent a major factor in the chronically relapsing nature of drug addiction. In drug dependent subjects these associations must be presumed to include associations linked to… read more here.
Keywords: compulsive alcohol; withdrawal; alcohol seeking; withdrawal states ... See more keywords
Alcohol Seeking Under Risk of Punishment Is Associated With Activation of Cortical and Subcortical Brain Regions
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2021.739681
Abstract: In humans, stimuli associated with alcohol availability can provoke relapse during abstinence. In this study, we investigated the role of discriminative stimuli (DS) in the control of alcohol seeking in two types of behavioral tests.… read more here.
Keywords: self administration; punishment; within session; alcohol self ... See more keywords