Neurogranin Regulates Alcohol Sensitivity through AKT Pathway in the Nucleus Accumbens
Sign Up to like & getrecommendations! Published in 2019 at "PROTEOMICS"
DOI: 10.1002/pmic.201900266
Abstract: Dysfunction of glutamate neurotransmission in the nucleus accumbens (NAc) has been implicated in the pathophysiology of alcohol use disorders (AUD). Neurogranin (Ng) is exclusively expressed in the brain and mediates N‐methyl‐d‐aspartate receptor (NMDAR) hypo‐function by… read more here.
Keywords: null mice; alcohol sensitivity; nucleus accumbens; mice ... See more keywords
Aging and circadian dysfunction increase alcohol sensitivity and exacerbate mortality in Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2017.07.014
Abstract: ABSTRACT Alcohol abuse is a rising problem in middle‐aged and older individuals resulting in serious health, family and economic consequences. Effective treatment necessitates the identification of factors influencing alcohol toxicity with aging. We investigated the… read more here.
Keywords: alcohol sensitivity; circadian dysfunction; circadian clock; sensitivity ... See more keywords
Moderation of Alcohol Craving Reactivity to Drinking-Related Contexts by Individual Differences in Alcohol Sensitivity: An Ecological Investigation
Sign Up to like & getrecommendations! Published in 2018 at "Experimental and Clinical Psychopharmacology"
DOI: 10.1037/pha0000206
Abstract: Laboratory cue exposure investigations have demonstrated that, relative to drinkers who report a high sensitivity to the pharmacologic effects of alcohol, low-sensitivity (LS) drinkers show exaggerated neurocognitive and behavioral reactivity to alcohol-related stimuli. The current… read more here.
Keywords: alcohol craving; differences alcohol; alcohol sensitivity; individual differences ... See more keywords
Effect of Alcohol Sensitivity in Healthy Young Adults on Breath Pharmacokinetics of Acetaldehyde After Mouth Washing with Alcohol
Sign Up to like & getrecommendations! Published in 2018 at "Alcoholism: Clinical and Experimental Research"
DOI: 10.1111/acer.13878
Abstract: BACKGROUND Acetaldehyde is causally related to head and neck cancer. Individuals with aldehyde dehydrogenase 2 deficiency experience alcohol sensitivity and are referred to as "flushers" because of their skin-flushing response to high blood acetaldehyde levels… read more here.
Keywords: breath; washing alcohol; alcohol sensitivity; mouth washing ... See more keywords
Meta‐Analysis of Genetic Influences on Initial Alcohol Sensitivity
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DOI: 10.1111/acer.13896
Abstract: BACKGROUND Previous studies indicate that low initial sensitivity to alcohol may be a risk factor for later alcohol misuse. Evidence suggests that initial sensitivity is influenced by genetic factors, but few molecular genetic studies have… read more here.
Keywords: alcohol sensitivity; initial alcohol; sensitivity; alcohol ... See more keywords
Influence of alcohol sensitivity on bone metastases and skeletal-related events in primary operable breast cancer: A retrospective cohort study
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0269335
Abstract: Background Bone metastases in breast cancer patients are a common concern for medical doctors and dentists. Bone-modifying agents, which are necessary to prevent skeletal-related events (SREs), are associated with osteonecrosis of the jaw as an… read more here.
Keywords: breast cancer; alcohol sensitivity; bone metastases; sensitivity ... See more keywords
Acetaldehyde Enhances Alcohol Sensitivity and Protects against Alcoholism: Evidence from Alcohol Metabolism in Subjects with Variant ALDH2*2 Gene Allele
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11081183
Abstract: Alcoholism is a complex behavior trait influenced by multiple genes as well as by sociocultural factors. Alcohol metabolism is one of the biological determinants that can significantly influence drinking behaviors. Alcohol sensitivity is thought to… read more here.
Keywords: alcohol sensitivity; alcohol metabolism; alcohol; adh1b aldh2 ... See more keywords