The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis
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DOI: 10.1002/hep.29623
Abstract: Intestinal dysbiosis is implicated in alcoholic hepatitis (AH). However, changes in the circulating microbiome, its association with the presence and severity of AH, and its functional relevance in AH is unknown. Qualitative and quantitative assessment… read more here.
Keywords: changes circulating; functional metagenomics; alcoholic hepatitis; hepatology ... See more keywords
Letter to the editor: The role of acute‐on‐chronic liver failure in predicting recovery in severe alcoholic hepatitis
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DOI: 10.1002/hep.32495
Abstract: To the editor, We read with great interest the study by Musto et al. entitled “Recovery and outcomes of patients denied early liver transplantation for severe alcoholic hepatitis.” In the paper by Musto and colleagues,… read more here.
Keywords: liver failure; aclf grade; alcoholic hepatitis; recovery ... See more keywords
Emergence of highly profibrotic and proinflammatory Lrat+ Fbln2+ hepatic stellate cell subpopulation in alcoholic hepatitis.
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DOI: 10.1002/hep.32793
Abstract: BACKGROUND AND AIMS Relative roles of hepatic stellate cells (HSCs) and portal fibroblasts (PFs) in alcoholic hepatitis (AH) are unknown. We aimed to identify subpopulations of Col1a1- expressing cells in a mouse AH model by… read more here.
Keywords: fbln2 cells; lrat fbln2; hepatic stellate; lrat ... See more keywords
Debate on Selection Criteria for Liver Transplantation for Alcoholic Hepatitis: Tighten or Loosen?
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DOI: 10.1002/lt.25783
Abstract: Although liver transplantation (LT) for alcohol‐associated liver disease (ALD) is a well‐accepted practice, LT for severe alcoholic hepatitis (AH) remains controversial due to concerns about the limited organ supply and the risk of return to… read more here.
Keywords: alcoholic hepatitis; selection criteria; transplantation; liver transplantation ... See more keywords
Clinical and microbiological features of infection in alcoholic hepatitis: an international cohort study
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DOI: 10.1007/s00535-017-1336-z
Abstract: BackgroundPrevious studies have described the clinical impact of infection in alcoholic hepatitis (AH) but none have comprehensively explored the aetiopathogenesis of infection in this setting. We examined the causes, consequences and treatment of infection in… read more here.
Keywords: infection; clinical microbiological; cohort; infection alcoholic ... See more keywords
Changes in Serum Myostatin Levels in Alcoholic Hepatitis Correlate with Improvement in MELD
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DOI: 10.1007/s10620-020-06632-5
Abstract: Alcoholic hepatitis (AH) is a serious clinical syndrome often associated with muscle wasting. Myostatin, a member of the transforming growth factor-β superfamily, has been studied in diseases with muscle wasting; however, the role of myostatin… read more here.
Keywords: myostatin; serum myostatin; myostatin levels; meld ... See more keywords
Biomarkers of endothelial dysfunction in alcoholic hepatitis
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DOI: 10.1007/s12072-021-10202-w
Abstract: Alcoholic hepatitis (AH) is a severe form of alcohol-associated liver disease (ALD) with high short-term mortality attributed to hepatic decompensation, renal failure, bacterial infection, or portal hypertension [1, 2]. Although mechanisms of pathogenesis require further… read more here.
Keywords: portal hypertension; alcoholic hepatitis; endothelial dysfunction; disease ... See more keywords
Good outcome of living donor liver transplantation for severe alcoholic hepatitis not responding to medical management: A single center experience of 39 patients.
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DOI: 10.1016/j.alcohol.2018.07.009
Abstract: INTRODUCTION There are limited data on outcomes of living donor liver transplantation (LDLT) for patients with severe alcoholic hepatitis. METHODS The study included LDLT recipients for severe alcoholic hepatitis (n = 39) who did not improve with… read more here.
Keywords: hepatitis; severe alcoholic; liver transplantation; donor liver ... See more keywords
Granulocyte colony stimulating factor: A potential therapeutic rescue in severe alcoholic hepatitis and decompensated cirrhosis.
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DOI: 10.1016/j.aohep.2020.04.011
Abstract: Liver cirrhosis accounts for over 2 million deaths annually worldwide. A subset of these patients - those with alcoholic hepatitis and decompensated cirrhosis, have abysmal short-term survival. Liver transplant is the only intervention of proven… read more here.
Keywords: cirrhosis; hepatitis decompensated; colony stimulating; decompensated cirrhosis ... See more keywords
Transplants for Acute Alcoholic Hepatitis: Controversies and Early Successes.
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DOI: 10.1016/j.cld.2020.08.010
Abstract: Liver transplant for severe alcohol-associated hepatitis remains a controversial practice despite evidence for a substantial survival benefit compared with medical therapy and posttransplant alcohol relapse rates comparable with previously published studies in alcohol-associated cirrhosis. The… read more here.
Keywords: alcohol associated; hepatitis; transplants acute; hepatitis controversies ... See more keywords
Homozygosity for rs738409:G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis.
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DOI: 10.1016/j.jhep.2017.01.018
Abstract: BACKGROUND & AIMS Carriage of rs738409:G in PNPLA3 is associated with an increased risk of developing alcohol-related cirrhosis and has a significant negative effect on survival. Short-term mortality in patients with severe alcoholic hepatitis is… read more here.
Keywords: rs738409 pnpla3; alcoholic hepatitis; severe alcoholic; mortality ... See more keywords