Divergent Synthesis of gem-Difluorinated Oxa-Spirocyclohexadienones by One-Pot Sequential Reactions of p-Hydroxybenzyl Alcohols with Difluoroenoxysilanes.
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DOI: 10.1021/acs.orglett.2c00550
Abstract: A new efficient formal [2 + 3] cyclization of p-hydroxybenzyl alcohols with difluoroenoxysilanes has been established. This convenient one-pot sequential procedure enables the divergent construction of highly functionalized gem-difluorinated oxa-spirocyclohexadienones under mild conditions. As opposed… read more here.
Keywords: difluorinated oxa; alcohols difluoroenoxysilanes; gem difluorinated; one pot ... See more keywords