β-amino alcohols and their respective 2-phenyl-N-alkyl aziridines as potential DNA minor groove binders.
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DOI: 10.1016/j.ejmech.2018.07.055
Abstract: It is known that aziridines and nitrogen mustards exert their biological activities, especially in chemotherapy, via DNA alkylation. The studied scaffold, 2-phenyl-1-aziridine, provides a distinct conformation compared to commonly used aziridines, and therefore, leads to… read more here.
Keywords: dna; alcohols respective; minor groove; amino alcohols ... See more keywords