NAD+ promotes assembly of the active tetramer of aldehyde dehydrogenase 7A1
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13238
Abstract: Nicotinamide adenine dinucleotide (NAD) is the redox cofactor of many enzymes, including the vast aldehyde dehydrogenase (ALDH) superfamily. Although the function of NAD(H) in hydride transfer is established, its influence on protein structure is less… read more here.
Keywords: nad promotes; promotes assembly; tetramer; assembly active ... See more keywords
Production of retinoic acid by engineered Saccharomyces cerevisiae using an endogenous aldehyde dehydrogenase
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28192
Abstract: Retinoic acid (RA), a vitamin A (retinol)‐derived lipophilic compound, is involved in various physiological functions. The demand for RA is growing in the pharmaceutical industry, but RA biosynthesis is still in its infancy compared to… read more here.
Keywords: aldehyde dehydrogenase; dehydrogenase; retinoic acid; endogenous aldehyde ... See more keywords
Aldehyde Dehydrogenase 2 (ALDH2) and Aging: Is There a Sensible Link?
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-6260-6_15
Abstract: Aging is a complex irreversible biological process associated with increased prevalence of chronic disease and high healthcare burden. Several theories have been proposed for the biology of aging including free radical accumulation, DNA damage, apoptosis,… read more here.
Keywords: dehydrogenase aldh2; aldh2 aging; biology; aldehyde dehydrogenase ... See more keywords
Aldehyde Dehydrogenase 2 and Heart Failure.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-6260-6_5
Abstract: Heart failure (HF) is a structural or functional cardiac abnormal syndrome characterized with series of symptoms and signs such as breathlessness, fatigue, pulmonary crackles, and peripheral edema. Being a terminal phase of most myocardial lesions,… read more here.
Keywords: heart; dehydrogenase heart; heart failure; biology ... See more keywords
Transgenic tobacco co-expressing flavodoxin and betaine aldehyde dehydrogenase confers cadmium tolerance through boosting antioxidant capacity.
Sign Up to like & getrecommendations! Published in 2021 at "Protoplasma"
DOI: 10.1007/s00709-021-01714-1
Abstract: Excessive heavy metal (HM) levels in soil have become a source of concern due to their adverse effects on human health and the agriculture industry. Soil contamination by HMs leads to an accumulation of reactive… read more here.
Keywords: tobacco; aldehyde dehydrogenase; betaine; betaine aldehyde ... See more keywords
Identification of a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.12.171
Abstract: Retinoic acid signalling is generally considered to be of animal origin. Recently, retinoic acid has been identified in cyanobacteria, yet no mechanism for its production has been identified. Here, we characterise for the first time… read more here.
Keywords: dehydrogenase; cyanobacterial aldehyde; retinoic acid; aldehyde dehydrogenase ... See more keywords
Geotrichum candidum aldehyde dehydrogenase-inorganic nanocrystal with enhanced activity.
Sign Up to like & getrecommendations! Published in 2021 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2021.109866
Abstract: A novel Geotrichum candidum aldehyde dehydrogenase (GcALDH) effectively oxidized aldehydes to carboxylic acids under mild conditions. Nonetheless, the free form of GcALDH still had a limitation in stability and recyclability. Herein, to overcome these limitations,… read more here.
Keywords: aldehyde dehydrogenase; candidum aldehyde; inorganic nanocrystal; geotrichum candidum ... See more keywords
Thymoquinone binds and activates human salivary aldehyde dehydrogenase: Potential therapy for the mitigation of aldehyde toxicity and maintenance of oral health.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.04.112
Abstract: Human salivary aldehyde dehydrogenase (hsALDH) is a very important anti-oxidant enzyme present in the saliva. It is involved in the detoxification of toxic aldehydes and maintenance of oral health. Reduced level of hsALDH activity is… read more here.
Keywords: hsaldh; maintenance oral; human salivary; salivary aldehyde ... See more keywords
Inhibition of Zea mays coniferyl aldehyde dehydrogenase by daidzin: A potential approach for the investigation of lignocellulose recalcitrance
Sign Up to like & getrecommendations! Published in 2020 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2019.11.024
Abstract: Abstract Coniferyl aldehyde dehydrogenase (CALDH) catalyzes the oxidation of coniferyl aldehyde to ferulic acid. Because ferulic acid has a relevant role in the structure and recalcitrance of the cell wall, inhibition of CALDH can reduce… read more here.
Keywords: coniferyl aldehyde; inhibition; zmayscaldh; zea mays ... See more keywords
Oxidation of aromatic and aliphatic aldehydes to carboxylic acids by Geotrichum candidum aldehyde dehydrogenase
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron"
DOI: 10.1016/j.tet.2020.131387
Abstract: Abstract Oxidation reaction is one of the most important and indispensable organic reactions, so that green and sustainable catalysts for oxidation are necessary to be developed. Herein, biocatalytic oxidation of aldehydes was investigated, resulted in… read more here.
Keywords: oxidation; geotrichum candidum; candidum aldehyde; carboxylic acids ... See more keywords
Importance of the C-Terminus of Aldehyde Dehydrogenase 7A1 for Oligomerization and Catalytic Activity.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00803
Abstract: Aldehyde dehydrogenase 7A1 (ALDH7A1) catalyzes the terminal step of lysine catabolism, the NAD+-dependent oxidation of α-aminoadipate semialdehyde to α-aminoadipate. Structures of ALDH7A1 reveal the C-terminus is a gate that opens and closes in response to… read more here.
Keywords: state; terminus; dehydrogenase 7a1; catalytic activity ... See more keywords