Synthesis of β-Ketonitriles via N-Heterocyclic-Carbene-Catalyzed Radical Coupling of Aldehydes and Azobis(isobutyronitrile).
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DOI: 10.1021/acs.orglett.3c01168
Abstract: Herein, an NHC (N-heterocyclic carbene)-catalyzed radical coupling reaction between aldehydes and azobis(isobutyronitrile) (AIBN) has been developed. This method provides an efficient and convenient approach for the synthesis of β-ketonitriles containing a quaternary carbon center (31… read more here.
Keywords: aldehydes azobis; azobis isobutyronitrile; catalyzed radical; carbene catalyzed ... See more keywords