UPLC-MS-based metabolomics reveals metabolic dysregulation in ALDH1A1-overexpressed lung adenocarcinoma cells
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DOI: 10.1007/s11306-019-1514-5
Abstract: IntroductionSpecific oncogenotypes can produce distinct metabolic changes in cancer. Recently it is considered that metabolic reprograming contributes heavily to drug resistance. Aldehyde dehydrogenase 1A1 (ALDH1A1), is overexpressed in drug resistant lung adenocarcinomas and may be… read more here.
Keywords: lung adenocarcinoma; drug; resistance; aldh1a1 ... See more keywords
Multifaceted Regulation of ALDH1A1 by Cdk5 in Alzheimer’s Disease Pathogenesis
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DOI: 10.1007/s12035-018-1114-9
Abstract: This study revealed multifaceted regulation of ALDH1A1 by Cdk5 in Alzheimer’s disease (AD) pathogenesis. ALDH1A1 is a multifunctional enzyme with dehydrogenase, esterase, and anti-oxidant activities. ALDH1A1 is also a major regulator of retinoic acid (RA)… read more here.
Keywords: cdk5; disease; multifaceted regulation; aldh1a1 ... See more keywords
Unintended effects of proton pump inhibitors (PPIs) in patients with glioblastoma (GBM): A double-edged sword
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DOI: 10.1093/nop/npac035
Abstract: A vast literature demonstrates that aldehyde dehydrogenase-1A1 (ALDH1A1) mediates therapy resistance and is associated with poor prognosis across human cancers. In glioblastoma (GBM), ALDH1A1 expression above vs below the mean causes temozolomide and radiation resistance… read more here.
Keywords: pump inhibitors; proton pump; inhibitors ppis; glioblastoma gbm ... See more keywords
Synaptic dysfunction of Aldh1a1 neurons in the ventral tegmental area causes impulsive behaviors
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DOI: 10.1186/s13024-021-00494-9
Abstract: Background Aldh1a1 neurons are a subtype of gamma-aminobutyric acid (GABA) inhibitory neurons that use Aldh1a1 rather than glutamate decarboxylase (GAD) as an enzyme for synthesizing GABA transmitters. However, the behaviors and circuits of this newly… read more here.
Keywords: aldh1a1; mice; aldh1a1 neurons; synaptic dysfunction ... See more keywords
Cancer stem cell markers CD44v9+/CD133- are associated with low apoptosis in both sporadic and ulcerative colitis-associated colorectal cancers.
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DOI: 10.14670/hh-18-445
Abstract: OBJECTIVE To elucidate tumor cell behavior associated with cancer stem cell (CSC) marker expression, the expression of CD133, CD44v9, and ALDH1A1, which are considered markers of CSCs, was examined in sporadic and ulcerative colitis (UC)-associated… read more here.
Keywords: stem cell; cancer stem; cd133; expression ... See more keywords