Aldehyde dehydrogenase‐2 (ALDH2) opposes hepatocellular carcinoma progression by regulating AMP‐activated protein kinase signaling in mice
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.29006
Abstract: Potential biomarkers that can be used to determine prognosis and perform targeted therapies are urgently needed to treat patients with hepatocellular carcinoma (HCC). To meet this need, we performed a screen to identify functional genes… read more here.
Keywords: protein; hepatocellular carcinoma; hcc; amp activated ... See more keywords
Association of low‐activity ALDH2 and alcohol consumption with risk of esophageal cancer in Chinese adults: A population‐based cohort study
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31566
Abstract: Existing evidence remains inconclusive as to how the association between inactive ALDH2 and esophageal cancer (EC) depends on alcohol consumption. The study is based on the China Kadoorie Biobank cohort, with 10 years follow‐up of… read more here.
Keywords: risk; response; among male; cancer ... See more keywords
ALDH2 Polymorphism and Ethanol Consumption: A Genetic-Environmental Interaction in Carcinogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-6260-6_14
Abstract: Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme in the detoxification of toxic aldehydes, especially acetaldehyde, which is commonly considered as a carcinogen. ALDH2 mutation and impaired enzymatic activity will cause acetaldehyde accumulation and thus… read more here.
Keywords: interaction carcinogenesis; genetic environmental; environmental interaction; consumption ... See more keywords
Aldehyde Dehydrogenase 2 (ALDH2) and Aging: Is There a Sensible Link?
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-6260-6_15
Abstract: Aging is a complex irreversible biological process associated with increased prevalence of chronic disease and high healthcare burden. Several theories have been proposed for the biology of aging including free radical accumulation, DNA damage, apoptosis,… read more here.
Keywords: dehydrogenase aldh2; aldh2 aging; biology; aldehyde dehydrogenase ... See more keywords
A comparison of CRISPR/Cas9 and siRNA-mediated ALDH2 gene silencing in human cell lines
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-018-1420-y
Abstract: Gene knockdown and knockout using RNAi and CRISPR/Cas9 allow for efficient evaluation of gene function, but it is unclear how the choice of technology can influence the results. To compare the phenotypes obtained using siRNA… read more here.
Keywords: crispr cas9; gene; cell; cas9 ... See more keywords
ALDH2 Protects Against Ischemic Stroke in Rats by Facilitating 4-HNE Clearance and AQP4 Down-Regulation
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2549-0
Abstract: Aldehyde dehydrogenase 2 (ALDH2) is a new therapeutic target in the central nervous system. However, the association between ALDH2 and brain edema following ischemic stroke (IS) remains unclear. The present study was investigated to whether… read more here.
Keywords: brain edema; ischemic stroke; hne clearance; brain ... See more keywords
ALDH2 restores exhaustive exercise-induced mitochondrial dysfunction in skeletal muscle.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.02.124
Abstract: BACKGROUND Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is highly expressed in heart and skeletal muscles, and is the major enzyme that metabolizes acetaldehyde and toxic aldehydes. The cardioprotective effects of ALDH2 during cardiac ischemia/reperfusion injury have… read more here.
Keywords: skeletal muscle; exercise induced; exhaustive exercise; exercise ... See more keywords
Acetaldehyde Dehydrogenase 2(ALDH2) in Atherosclerosis: Beyond Detoxification of Reactive Aldehydes
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.191
Abstract: Previous studies have linked human polymorphisms of ALDH2 to cardiovascular diseases but the underlying mechanisms remain elusive. Here we investigated the role of ALDH2 in atherosclerosis using a murine model of low density lipoprotein receptor… read more here.
Keywords: acetaldehyde dehydrogenase; aldh2 atherosclerosis; atherosclerosis; detoxification reactive ... See more keywords
Activation of mitochondrial aldehyde dehydrogenase (ALDH2) by ALDA-1 reduces both the acquisition and maintenance of ethanol intake in rats: A dual mechanism?
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.12.001
Abstract: ABSTRACT A number of pre‐clinical studies have shown that brain‐generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic intake maintenance appears to be mediated by… read more here.
Keywords: acquisition; ethanol intake; maintenance; aldh2 ... See more keywords
Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz091
Abstract: Abstract Alcohol consumption is the key risk factor for the development of esophageal squamous cell carcinoma (ESCC), and acetaldehyde, a metabolite of alcohol, is an alcohol-derived major carcinogen that causes DNA damage. Aldehyde dehydrogenase2 (ALDH2)… read more here.
Keywords: dna damage; knock mice; alcohol; aldh2 ... See more keywords
SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant
Sign Up to like & getrecommendations! Published in 2023 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abp9952
Abstract: The common aldehyde dehydrogenase 2 (ALDH2) alcohol flushing variant known as ALDH2*2 affects ∼8% of the world’s population. Even in heterozygous carriers, this missense variant leads to a severe loss of ALDH2 enzymatic activity and… read more here.
Keywords: cad; aldh2; dysfunction; aldh2 alcohol ... See more keywords