Causes and possibilities to circumvent cyclophosphamide toxicity
Sign Up to like & getrecommendations! Published in 2020 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000000912
Abstract: Cyclophosphamide is an inert prodrug converted into 4-hydroxycyclophosphamide (OHCP) by hepatic hydroxylation. OHCP is in equilibrium with its tautomeric aldophosphamide (ALDO). From ALDO, the cytotoxic active metabolites are formed enzymatically by phosphodiesterases; these are the… read more here.
Keywords: toxicity; pam; causes possibilities; aldo ... See more keywords
SUN-193 Effects of Aldosterone on Ovarian Steroidogenesis and Involvement of BMP Action in Rat Granulosa Cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sun-193
Abstract: Abstract Many local factors expressed in the ovary are involved in folliculogenesis. Among these, the ovarian renin-angiotensin system is critical for normal processes of follicle development, steroidogenesis and ovulation. In various clinical conditions such as… read more here.
Keywords: steroidogenesis; granulosa; production; aldo ... See more keywords
Aldosterone-Induced Sarco/Endoplasmic Reticulum Ca2+ Pump Upregulation Counterbalances Cav1.2-Mediated Ca2+ Influx in Mesenteric Arteries
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.834220
Abstract: In mesenteric arteries (MAs), aldosterone (ALDO) binds to the endogenous mineralocorticoid receptor (MR) and increases the expression of the voltage-gated L-type Cav1.2 channel, an essential ion channel for vascular contraction, sarcoplasmic reticulum (SR) Ca2+ store… read more here.
Keywords: aldo; pump; reticulum ca2; mesenteric arteries ... See more keywords