Practical Access to Trisubstituted Morita‐Baylis‐Hillman‐Type Products Through Copper‐catalyzed Reductive Aldol Reactions of Alkynones
Sign Up to like & getrecommendations! Published in 2024 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202400422
Abstract: We report a convenient and diastereoselective copper‐catalyzed reductive alkynone aldol addition to aldehydes, with pinacolborane as stoichiometric reductant, that results in the generation of densely functionalized, trisubstituted (Z)‐enone products analogous to Morita‐Baylis‐Hillman adducts. We demonstrate… read more here.
Keywords: aldol; practical access; morita baylis; baylis hillman ... See more keywords
NHC-Mediated Stetter-Aldol and Imino-Stetter-Aldol Domino Cyclization to Naphthalen-1(2H)-ones and Isoquinolines.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00337
Abstract: N-Heterocyclic carbene-catalyzed tandem Stetter-aldol reaction of phthalaldehyde and α,β-unsaturated ketimines has been developed to afford functionalized naphthalen-1(2H)-one derivatives as the formal [4+2] annulation product. Interestingly, the reaction of aldimines led to the formation of isoquinoline… read more here.
Keywords: nhc mediated; mediated stetter; aldol; aldol imino ... See more keywords
Pyrrolidine-oxadiazolone conjugate as new organocatalyst for asymmetric aldol condensation
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DOI: 10.1080/00397911.2023.2205593
Abstract: Abstract A proline-based, chiral bi-functional organocatalyst containing both pyrrolidine and oxadiazolone heterocycle, has been successfully applied for stereoselective aldol reactions. The replacement of polar -COOH group of proline with bioisostere oxadiazolone ring provides excellent solubility… read more here.
Keywords: pyrrolidine oxadiazolone; condensation; oxadiazolone conjugate; organocatalyst ... See more keywords
Bioinspired Polymer-Bound Organocatalysts for Direct Asymmetric Aldol Reaction: Experimental and Computational Studies
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DOI: 10.3390/catal9050398
Abstract: A series of poly(2-oxazoline) (POX) derivatives bearing prolinamide pendants were designed as organocatalysts and evaluated in the direct asymmetric aldol reaction between aromatic aldehydes and cyclic ketones. The structural variation of the alkyl spacer connecting… read more here.
Keywords: aldol reaction; bound; aldol; reaction ... See more keywords