Articles with "aldol cascade" as a keyword



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Organocatalytic Enantioselective Vinylogous Michael-Aldol Cascade for the Synthesis of Spirocyclic Compounds.

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Published in 2017 at "Organic letters"

DOI: 10.1021/acs.orglett.7b02085

Abstract: Enantioselective synthesis of pyrazolone-fused spirocyclohexenols by the secondary amine-catalyzed cascade reaction of α,β-unsaturated aldehydes with α-arylidene pyrazolinones is reported. This formal [3 + 3] organocascade reaction proceeds through a vinylogous Michael-aldol sequence to furnish the… read more here.

Keywords: aldol cascade; michael aldol; organocatalytic enantioselective; vinylogous michael ... See more keywords
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Organocatalytic sulfa-Michael/aldol cascade: constructing functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter

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Published in 2018 at "RSC Advances"

DOI: 10.1039/c8ra04325f

Abstract: A practical sulfa-Michael/aldol cascade reaction of 1,4-dithiane-2,5-diol and α-aryl-β-nitroacrylates has been developed, which allows efficient access to functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter in moderate to good yields with high enantioselectivities. read more here.

Keywords: aldol cascade; dihydrothiophenes bearing; sulfa michael; functionalized dihydrothiophenes ... See more keywords