Diarylprolinol as an Effective Organocatalyst in Asymmetric Cross-aldol Reactions of Two Different Aldehydes.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical record"
DOI: 10.1002/tcr.202200159
Abstract: The aldol reaction is one of the most important carbon-carbon bond-forming reactions in organic chemistry. Asymmetric direct cross-aldol reaction of two different aldehydes has been regarded as a difficult reaction because of the side reactions… read more here.
Keywords: two different; reaction; aldol reaction; cross aldol ... See more keywords
Bipyridine-Proline Grafted Silicas with Different Mesopore Structures: Their Catalytic Performance in Asymmetric Aldol Reaction and Structure Effect
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DOI: 10.1007/s10562-018-2421-5
Abstract: A series of immobilized bipyridine-proline based on mesoporous silica with different structures were synthesized via grafting followed by coordination method. All catalysts were used in asymmetric aldol reaction of cyclohexanone with 4-nitrobenzaldehyde, and their catalytic… read more here.
Keywords: bipyridine proline; aldol reaction; performance; asymmetric aldol ... See more keywords
Recyclable Helical Poly(phenyl isocyanide)-Supported l-Proline Catalyst for Direct Asymmetric Aldol Reaction in Brine
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DOI: 10.1007/s10562-020-03369-8
Abstract: Abstract A novel helical poly(phenyl isocyanide) bearing Boc protected l -proline pendants (poly- 1 m ) was designed and synthesized. Removed the protecting Boc groups on the l -proline pendants led to the formation of… read more here.
Keywords: helical poly; reaction; aldol reaction; poly phenyl ... See more keywords
Carane amino alcohols as organocatalysts in asymmetric aldol reaction of isatin with acetone
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DOI: 10.1007/s11172-017-1730-y
Abstract: Carane-derived β-amino alcohols with amino and hydroxy groups at positions 3 and 4 differing in their mutual arrangement and configuration were synthesized. Their application as organocatalysts in the asymmetric aldol reaction of isatin with acetone… read more here.
Keywords: isatin acetone; aldol reaction; organocatalysts asymmetric; amino alcohols ... See more keywords
Monofunctional primary amine: A new class of organocatalyst for asymmetric Aldol reaction
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DOI: 10.1007/s12039-017-1237-y
Abstract: AbstractA new class of organocatalysts involving a primary amine as the only functional group is developed for catalytic asymmetric aldol reaction of cyclohexanone/cyclopentanone with various aryl aldehydes in the presence of benzoic acid as an… read more here.
Keywords: new class; aldol reaction; reaction; primary amine ... See more keywords
β-Hydroxy Carbonyl Compounds Via Aldol Reaction: Single Crystal Investigation and Quantum Chemical Exploration for the Unveiling of Supramolecular Behavior
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DOI: 10.1016/j.molstruc.2021.130650
Abstract: Abstract Aldol reaction is a carbon-carbon bond forming chemical reaction for synthesis of β-hydroxy carbonyl compounds. In the current research work, we have synthesizedβ-hydroxy carbonyl compounds i.e 2-(hydroxy(4-nitrophenyl)methyl)cyclohexan-1-one (1) 2-(hydroxy(o-tolyl)methyl)cyclohexan-1-one (2) using base mediated aldol… read more here.
Keywords: hydroxy carbonyl; reaction; aldol reaction; carbonyl compounds ... See more keywords
Total synthesis of (+)-methynolide using a Ti-mediated aldol reaction of a lactyl-bearing oxazolidin-2-one, and a vinylogous Mukaiyama aldol reaction
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DOI: 10.1016/j.tet.2017.03.093
Abstract: A bstract A highly convergent total synthesis of (+)-methynolide, based on two types of stereoselective aldol reaction, was achieved. The C1-C8 and C9-C11 fragments of (+)-methynolide were prepared by a vinylogous Mukaiyama aldol reaction using… read more here.
Keywords: aldol reaction; synthesis methynolide; total synthesis; reaction ... See more keywords
Catalytic asymmetric borylative aldol reaction of 5,6-dihydro-2H-pyran-2-one and ketones
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DOI: 10.1016/j.tet.2018.11.041
Abstract: Abstract A copper(I)-catalyzed asymmetric borylative aldol reaction of 5,6-dihydro-2H-pyran-2-one and simple ketones (including aromatic ketones and an aliphatic ketone) was disclosed, which afforded a series of chiral diols after an oxidative work-up in moderate yields… read more here.
Keywords: aldol reaction; dihydro pyran; asymmetric borylative; borylative aldol ... See more keywords
The vinylogous aldol reaction of N-Sulfinyl metallodienamines
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DOI: 10.1016/j.tet.2019.130901
Abstract: Abstract The discovery and development of the vinylogous aldol reaction of N-sulfinyl metallodienamines with aldehydes and ketones is described. The diastereoselectivity of the reaction, first reported in 2017 as a key step in the total… read more here.
Keywords: reaction sulfinyl; aldol reaction; sulfinyl metallodienamines; vinylogous aldol ... See more keywords
Oxetane Intermediate during a Direct Aldol Reaction: Stereoselective [5 + 1] Annulation Affording Tetralines.
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DOI: 10.1021/acs.orglett.0c02816
Abstract: An oxetane intermediate during a direct aldol reaction was trapped with an internal aryl group to yield trans-tetraline products. The contribution of the oxetane intermediate was confirmed by 18O-isotope labeling experiments. read more here.
Keywords: reaction stereoselective; oxetane intermediate; intermediate direct; aldol reaction ... See more keywords
Asymmetric Synthesis of Functionalized 9-Methyldecalins Using a Diphenylprolinol-Silyl-Ether-Mediated Domino Michael/Aldol Reaction.
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DOI: 10.1021/acs.orglett.1c02196
Abstract: Substituted 9-methyldecalin derivatives containing an all carbon quaternary chiral center were synthesized with excellent enantioselectivity via an organocatalyst-mediated domino reaction. The first reaction is a diphenylprolinol silyl ether-mediated Michael reaction, and the second reaction is… read more here.
Keywords: diphenylprolinol silyl; mediated domino; aldol reaction; silyl ether ... See more keywords