Ginsenoside Rg1 protects H9c2 cells against nutritional stress‐induced injury via aldolase /AMPK/PINK1 signalling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29150
Abstract: Insufficient nutrients supply will greatly affect the function of cardiac myocytes. The adaptive responses of cardiac myocytes to nutritional stress are not fully known. Ginsenoside Rg1 is one of the most pharmacologically active components in… read more here.
Keywords: ginsenoside rg1; h9c2 cells; aldolase; nutritional stress ... See more keywords
Substitutions at a rheostat position in human aldolase A cause a shift in the conformational population
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4222
Abstract: Some protein positions play special roles in determining the magnitude of protein function: at such “rheostat” positions, varied amino acid substitutions give rise to a continuum of functional outcomes, from wild type (or enhanced), to… read more here.
Keywords: rheostat positions; human aldolase; substitutions rheostat; position human ... See more keywords
Aldolase C is a novel molecular marker for folliculo-stellate cells in rodent pituitary
Sign Up to like & getrecommendations! Published in 2020 at "Cell and Tissue Research"
DOI: 10.1007/s00441-020-03200-1
Abstract: The anterior pituitary gland is composed of five types of hormone-producing cells and folliculo-stellate cells. Folliculo-stellate cells do not produce anterior pituitary hormones but they are thought to play important roles as stem cells, phagocytes,… read more here.
Keywords: aldolase; folliculo stellate; marker; anterior pituitary ... See more keywords
The antitumor role of a newly discovered α-d-glucan from Holotrichia diomphalia Bates as a selective blocker of aldolase A.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2020.117532
Abstract: Aldolase A (ALDOA) facilitated aerobic glycolysis in cancer cells is a potential target in the treatment of hepatocellular carcinoma (HCC). However, only few effective inhibitors of ALDOA have been reported until now. In this research,… read more here.
Keywords: diomphalia bates; hdps 4ii; holotrichia diomphalia; aldolase ... See more keywords
Multi-reaction kinetic modeling for the peroxidase–aldolase cascade synthesis of a D-fagomine precursor
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Engineering Science"
DOI: 10.1016/j.ces.2021.116602
Abstract: Abstract The feasibility of a peroxidase–aldolase cascade reaction for the synthesis of therapeutically-valuable iminocyclitols is discussed herein. A two-enzyme system consisting of chloroperoxidase (CPO) and D-fructose-6-phosphate aldolase (FSA) was evaluated for the synthesis of a… read more here.
Keywords: peroxidase aldolase; synthesis fagomine; aldolase cascade; reaction ... See more keywords
One-Pot Biosynthesis of 2-Keto-4-hydroxybutyrate from Cheap C1 Compounds Using Rationally Designed Pyruvate Aldolase and Methanol Dehydrogenase.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c09108
Abstract: One-carbon chemicals (C 1s) are potential building blocks as they are cheap, sustainable, and abiotic components. Methanol-derived formaldehyde can be another versatile building block for the production of 2-keto-4-hydroxyacid derivatives that can be used for… read more here.
Keywords: methanol dehydrogenase; keto hydroxybutyrate; one pot; aldolase ... See more keywords
Bisphosphonate Inhibitors of Mammalian Glycolytic Aldolase.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01000
Abstract: The glycolytic enzyme aldolase is an emerging drug target in diseases such as cancer and protozoan infections which are dependent on a hyperglycolytic phenotype to synthesize adenosine 5'-triphosphate and metabolic precursors for biomass production. To… read more here.
Keywords: aldolase; inhibitors mammalian; mammalian glycolytic; bisphosphonate ... See more keywords
Identification and characterization of a deaminoneuraminic acid (Kdn)-specific aldolase from Sphingobacterium sp.
Sign Up to like & getrecommendations! Published in 2022 at "Glycobiology"
DOI: 10.1093/glycob/cwac053
Abstract: Sialic acid (Sia) is a group of acidic sugars with a nine-carbon backbone, and classified into three species based on the substituent group at C5 position: N-acetylneuraminic acid (Neu5Ac), N-glycolylneuraminic acid (Neu5Gc), and deaminoneuraminic acid… read more here.
Keywords: deaminoneuraminic acid; kdn; aldolase; kdn specific ... See more keywords
Multifunctional Fructose 1,6-Bisphosphate Aldolase as a Therapeutic Target
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.719678
Abstract: Fructose 1,6-bisphosphate aldolase is a ubiquitous cytosolic enzyme that catalyzes the fourth step of glycolysis. Aldolases are classified into three groups: Class-I, Class-IA, and Class-II; all classes share similar structural features but low amino acid… read more here.
Keywords: fructose bisphosphate; moonlighting functions; aldolase; target ... See more keywords
Identification of 2-keto-3-deoxy-d-Gluconate Kinase and 2-keto-3-deoxy-d-Phosphogluconate Aldolase in an Alginate-Assimilating Bacterium, Flavobacterium sp. Strain UMI-01
Sign Up to like & getrecommendations! Published in 2017 at "Marine Drugs"
DOI: 10.3390/md15020037
Abstract: Recently, we identified an alginate-assimilating gene cluster in the genome of Flavobacterium sp. strain UMI-01, a member of Bacteroidetes. Alginate lyase genes and a 4-deoxy-l-erythro-5-hexoseulose uronic acid (DEH) reductase gene in the cluster have already… read more here.
Keywords: keto deoxy; strain umi; aldolase; alginate ... See more keywords
Simple Enzyme Immobilization for Flow Chemistry? An Assessment of Available Strategies for an Acetaldehyde-Dependent Aldolase
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27196483
Abstract: Enzyme immobilization is a technology that enables (bio-)catalysts to be applied in continuous-flow systems. However, there is a plethora of immobilization methods available with individual advantages and disadvantages. Here, we assessed the influence of simple… read more here.
Keywords: immobilization; chemistry; affinity; flow ... See more keywords