Determination of the inhibition profiles of pyrazolyl–thiazole derivatives against aldose reductase and α‐glycosidase and molecular docking studies
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DOI: 10.1002/ardp.202000118
Abstract: Aldose reductase (AR) is the first and rate‐limiting enzyme of the polyol pathway, which converts glucose to sorbitol in an NADPH‐dependent reaction. α‐Glycosidase breaks down starch and disaccharides to glucose. Hence, inhibition of these enzymes… read more here.
Keywords: determination inhibition; glycosidase; aldose reductase; inhibition ... See more keywords
A new series of hydrazones as small‐molecule aldose reductase inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200570
Abstract: In the search for small‐molecule aldose reductase (AR) inhibitors, new tetrazole‐hydrazone hybrids (1–15) were designed. An efficient procedure was employed for the synthesis of compounds 1–15. All hydrazones were subjected to an in vitro assay… read more here.
Keywords: small molecule; reductase inhibitors; aldose reductase; molecule aldose ... See more keywords
Novel acetic acid derivatives containing quinazolin‐4(3H)‐one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors
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DOI: 10.1002/ddr.22031
Abstract: Aldose reductase (AR) is a crucial enzyme of the polyol pathway through which glucose is metabolized under conditions of hyperglycemia related to diabetes. A series of novel acetic acid derivatives containing quinazolin‐4(3H)‐one ring (1–22) was… read more here.
Keywords: derivatives containing; acid; aldose reductase; acetic acid ... See more keywords
An efficient synthesis of flavanones and their docking studies with aldose reductase
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DOI: 10.1007/s00044-017-1813-1
Abstract: A series of flavanone derivatives have been synthesized from 2-hydroxy acetophenone and benzaldehyde using fused calcium chloride in good to moderate yields, and their in vitro aldose reductase inhibitory activity has been tested on aldose… read more here.
Keywords: synthesis flavanones; efficient synthesis; aldose reductase; docking studies ... See more keywords
Prevention of tubulin/aldose reductase association delays the development of pathological complications in diabetic rats.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of physiology and biochemistry"
DOI: 10.1007/s13105-021-00820-1
Abstract: In recent studies, we found that compounds derived from phenolic acids (CAFs) prevent the formation of the tubulin/aldose reductase complex and, consequently, may decrease the occurrence or delay the development of secondary pathologies associated with… read more here.
Keywords: aldose reductase; tubulin aldose; diabetes mellitus; tubulin ... See more keywords
Protective effect of Pterocarpus marsupium bark extracts against cataract through the inhibition of aldose reductase activity in streptozotocin-induced diabetic male albino rats
Sign Up to like & getrecommendations! Published in 2018 at "3 Biotech"
DOI: 10.1007/s13205-018-1210-6
Abstract: The present study was aimed to investigate the protective effect of Pterocarpus marsupium bark extracts against cataract in streptozotocin-induced diabetic male albino rats. Aldose reductase is a key enzyme in the intracellular polyol pathway, which… read more here.
Keywords: bark; marsupium bark; aldose reductase; pterocarpus marsupium ... See more keywords
Determination of flavonoids from Perilla frutescens var. japonica seeds and their inhibitory effect on aldose reductase
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DOI: 10.1007/s13765-017-0260-5
Abstract: Perilla frutescens var. japonica (PF) is an annual aromatic herb has been consumed as a food ingredient and medicinal crop in Asian countries. To evaluate the therapeutic efficacy of aldose reductase (AR) inhibition, we tested… read more here.
Keywords: var japonica; aldose reductase; frutescens var; perilla frutescens ... See more keywords
Identification of new potent inhibitor of aldose reductase from Ocimum basilicum.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.08.011
Abstract: Recent efforts to develop cure for chronic diabetic complications have led to the discovery of potent inhibitors against aldose reductase (AKR1B1, EC 1.1.1.21) whose role in diabetes is well-evident. In the present work, two new… read more here.
Keywords: reductase; aldose reductase; ocimum basilicum; ic50 ... See more keywords
Role of aldose reductase in diabetes-induced retinal microglia activation.
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DOI: 10.1016/j.cbi.2019.01.020
Abstract: Diabetes-induced hyperglycemia plays a key pathogenic role in degenerative retinal diseases. In diabetic hyperglycemia, aldose reductase (AR) is elevated and linked to the pathogenesis of diabetic retinopathy (DR) and cataract. Retinal microglia (RMG), the resident… read more here.
Keywords: aldose reductase; retinal microglia; role; activation ... See more keywords
Acid Derivatives of Pyrazolo[1,5-a]pyrimidine as Aldose Reductase Differential Inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.07.008
Abstract: Aldose reductase (AKR1B1), the key enzyme of the polyol pathway, plays a crucial role in the development of long-term complications affecting diabetic patients. Nevertheless, the expedience of inhibiting this enzyme to treat diabetic complications has… read more here.
Keywords: reductase; differential inhibitors; aldose reductase; pyrazolo pyrimidine ... See more keywords
TonEBP/NFAT5 regulates downstream osmoregulatory proteins during freeze-thaw stress in the wood frog.
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DOI: 10.1016/j.cryobiol.2017.09.003
Abstract: Rana sylvatica, known as the wood frog, can survive extremely cold temperatures during winter by undergoing full-body freezing, where it tolerates freezing of 65-70% of its total body water. During freezing, cellular dehydration decreases damage… read more here.
Keywords: aldose reductase; osmoregulatory; freeze thaw; osmoregulatory proteins ... See more keywords