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   Articles with "aldosterone" as a keyword



Insights Into Aldosterone Regulation Through Pharmacokinetic-Pharmacodynamic Modeling of an Aldosterone Synthase Inhibitor.

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recommendations! Published in 2025 at "Clinical pharmacology and therapeutics"

DOI: 10.1002/cpt.70114

Abstract: Aldosterone is a mineralocorticoid hormone essential for regulating renal function and blood pressure. Despite its clinical relevance, key aspects of aldosterone pharmacokinetics (PK) and physiological dynamics remain incompletely understood. In serial stages, we developed a… read more here.

Keywords: aldosterone; aldosterone synthase; pharmacokinetic pharmacodynamic; production ... See more keywords

Role of Aldosterone in Renal Fibrosis.

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recommendations! Published in 2019 at "Advances in experimental medicine and biology"

DOI: 10.1007/978-981-13-8871-2_15

Abstract: Aldosterone is a mineralocorticoid hormone, as its main renal effect has been considered as electrolyte and water homeostasis in the distal tubule, thus maintaining blood pressure and extracellular fluid homeostasis through the activation of mineralocorticoid… read more here.

Keywords: fibrosis; aldosterone; renal fibrosis; factor ... See more keywords

Aldosterone stimulation mediates cardiac metabolism remodeling via Sirt1/AMPK signaling in canine model

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recommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"

DOI: 10.1007/s00210-019-01641-2

Abstract: Aldosterone (Aldo), a pivotal hormone that is ubiquitously expressed in systemic tissues of mammals, is a crucial factor in the pathogenesis of cardiac disease. Accumulating evidence suggests that disturbances in cell energy metabolism are involved… read more here.

Keywords: aldosterone stimulation; aldosterone; sirt1 ampk; metabolism ... See more keywords

Race, obesity, and the renin-angiotensin-aldosterone system: treatment response in children with primary hypertension

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recommendations! Published in 2017 at "Pediatric Nephrology"

DOI: 10.1007/s00467-017-3665-9

Abstract: BackgroundPediatric primary hypertension (HTN) is increasingly recognized, but the effect of patient characteristics such as obesity and race on treatment outcomes is not well described. The renin-angiotensin-aldosterone system (RAAS) may also contribute to HTN. We… read more here.

Keywords: aldosterone; treatment; year; race ... See more keywords
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Gene expression changes in the retina after systemic administration of aldosterone

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recommendations! Published in 2018 at "Japanese Journal of Ophthalmology"

DOI: 10.1007/s10384-018-0595-4

Abstract: PurposeRetinal ganglion cell (RGC) loss associated with thinning of the retinal nerve fiber layer without elevated intraocular pressure (IOP) occurs after the systemic administration of aldosterone. Since it is important to determine the mechanism of… read more here.

Keywords: administration aldosterone; gene expression; aldosterone; systemic administration ... See more keywords

The Effects of Verapamil, Hydralazine, and Doxazosin on Renin, Aldosterone, and the Ratio Thereof

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recommendations! Published in 2021 at "Cardiovascular Drugs and Therapy"

DOI: 10.1007/s10557-021-07262-3

Abstract: Hydralazine, doxazosin, and verapamil are currently recommended by the Endocrine Society as acceptable bridging treatment in those in whom full cessation of antihypertensive medication is infeasible during screening for primary aldosteronism (PA). This is under… read more here.

Keywords: aldosterone; ratio; hydralazine doxazosin; renin ... See more keywords

Aldosterone infusion into the 4th ventricle produces sodium appetite with baroreflex attenuation independent of renal or blood pressure changes

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recommendations! Published in 2018 at "Brain Research"

DOI: 10.1016/j.brainres.2018.06.023

Abstract: Aldosterone infusion into the 4th ventricle (4th V), upstream the nucleus of the solitary tract (NTS), produces strong 0.3 M NaCl intake. In the present study, we investigated whether aldosterone infusion into the 4th V activates… read more here.

Keywords: aldosterone; infusion; blood pressure; infusion 4th ... See more keywords
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Abstract 14538: MANP: A Novel Aldosterone Inhibitor: Potential Molecular Mechanisms in vitro in Human Adrenal Cells

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recommendations! Published in 2017 at "Circulation"

DOI: 10.1016/j.cardfail.2017.07.260

Abstract: Introduction: Aldosterone (Aldo) is synthesized and secreted by the adrenal cortex zona glomerulosa (ZG) cells. In cardiovascular (CV) disease Aldo is increased and plays a critical role in disease... read more here.

Keywords: 14538 manp; abstract 14538; novel aldosterone; aldosterone ... See more keywords

Solving a myth: Does boric acid stabilize aldosterone in urine at typical clinical laboratory storage conditions?

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recommendations! Published in 2019 at "Clinical biochemistry"

DOI: 10.1016/j.clinbiochem.2019.07.015

Abstract: Aldosterone is produced by the adrenal gland and plays an important role in blood pressure regulation and electrolyte hemostasis. Clinically, measurement of urine aldosterone provides evidence for the diagnosis of hyper- and hypo-aldosteronism. Urine specimen… read more here.

Keywords: aldosterone; typical clinical; aldosterone urine; clinical laboratory ... See more keywords

Migration from RIA to LC-MS/MS for aldosterone determination: Implications for clinical practice and determination of plasma and urine reference range intervals in a cohort of healthy Belgian subjects

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recommendations! Published in 2018 at "Clinical Mass Spectrometry"

DOI: 10.1016/j.clinms.2018.06.002

Abstract: Abstract Background Aldosterone measurement is critical for diagnosis of primary aldosteronism and disorders of the renin-angiotensin system. We developed an LC-MS/MS method for plasma and urinary aldosterone and compared it to our RIA method. We… read more here.

Keywords: plasma urine; reference interval; aldosterone; determination ... See more keywords

Essential role of ICAM-1 in aldosterone-induced atherosclerosis.

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recommendations! Published in 2017 at "International journal of cardiology"

DOI: 10.1016/j.ijcard.2017.01.013

Abstract: OBJECTIVE Elevated aldosterone is associated with increased risk of atherosclerosis complications, whereas treatment with mineralocorticoid receptor (MR) antagonists decreases the rate of cardiovascular events. Here we test the hypothesis that aldosterone promotes early atherosclerosis by… read more here.

Keywords: icam expression; aldosterone; icam; plaque ... See more keywords