Insights Into Aldosterone Regulation Through Pharmacokinetic-Pharmacodynamic Modeling of an Aldosterone Synthase Inhibitor.
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DOI: 10.1002/cpt.70114
Abstract: Aldosterone is a mineralocorticoid hormone essential for regulating renal function and blood pressure. Despite its clinical relevance, key aspects of aldosterone pharmacokinetics (PK) and physiological dynamics remain incompletely understood. In serial stages, we developed a… read more here.
Keywords: aldosterone; aldosterone synthase; pharmacokinetic pharmacodynamic; production ... See more keywords
Analysis of the Aldosterone Synthase (CYP11B2) and 11β-Hydroxylase (CYP11B1) Genes.
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DOI: 10.1007/978-1-4939-6625-7_11
Abstract: The aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1) enzymes are known to be important players in the development of hypertension. Sequencing of the CYP11B2 and CYP11B1 genes and quantification of their respective mRNAs is greatly complicated… read more here.
Keywords: aldosterone synthase; synthase cyp11b2; cyp11b2 hydroxylase; hydroxylase cyp11b1 ... See more keywords
Salt-dependent Blood Pressure in Human Aldosterone Synthase-Transgenic Mice
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DOI: 10.1038/s41598-017-00461-9
Abstract: Hypertension is one of the most important, preventable causes of premature morbidity and mortality in the developed world. Aldosterone is a major mineralocorticoid hormone that plays a key role in the regulation of blood pressure… read more here.
Keywords: blood pressure; mice; aldosterone synthase; aldosterone ... See more keywords
ALDOSTERONE SYNTHASE CYP11B2 (-344C/T) GENE POLYMORPHISM INFLUENCES RISK OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH ARTERIAL HYPERTENSION
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DOI: 10.1097/01.hjh.0000838032.16666.3c
Abstract: Objective: Renin-angiotensin aldosterone system plays a major role in blood pressure regulation. Aldosterone, synthesized in the adrenal cortex by aldosterone synthase is encoded by the cytochrome 11B2 aldosterone synthase gene (CYP11B2). The aim of the… read more here.
Keywords: ckd; disease; aldosterone synthase; gene ... See more keywords
Breaking down resistance: novel aldosterone synthase inhibitors in the management of resistant hypertension.
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DOI: 10.1097/hjh.0000000000004055
Abstract: This review aims to evaluate the impact of novel aldosterone synthase inhibitors, the first new class of antihypertensives in more than 20 years, on the management of resistant hypertension. We highlight the problem of resistant hypertension… read more here.
Keywords: hypertension; resistant hypertension; aldosterone synthase; synthase inhibitors ... See more keywords
First-in-Human Evaluation of [18F]AldoView: A Highly Selective PET Tracer for Aldosterone Synthase Imaging in Primary Aldosteronism.
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DOI: 10.1097/rlu.0000000000006014
Abstract: OBJECTIVES Aldosterone synthase (CYP11B2) is overexpressed in primary aldosteronism (PA), making it a promising target for imaging. This first-in-human study evaluates the safety and feasibility of [18F]AldoView, a highly selective PET tracer targeting CYP11B2, for… read more here.
Keywords: 18f aldoview; aldoview; primary aldosteronism; first human ... See more keywords
Abstract 4357375: Safety and Efficacy of the Aldosterone Synthase Inhibitor Osilodrostat in Primary Hypertension: A Retrospective Cohort Analysis
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DOI: 10.1161/circ.152.suppl_3.4357375
Abstract: Background: Osilodrostat, the first-generation aldosterone synthase inhibitor, lowered aldosterone and blood pressure in phase II studies, but its real-world safety and efficacy in primary hypertension remain undefined. Methods: We used the TriNetX Global Collaborative Network… read more here.
Keywords: adverse events; primary hypertension; hypertension; safety ... See more keywords
Specific Aldosterone Synthase Inhibition: A Potential Improvement Over Mineralocorticoid Receptor Antagonism?
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DOI: 10.1161/hypertensionaha.116.07939
Abstract: See related article, pp 189–196 We have come to appreciate the many physiological and pathophysiological functions of adrenal steroid hormones in health and disease and the benefits and adverse effects of therapeutic manipulations. Glucocorticoids are… read more here.
Keywords: mineralocorticoid receptor; synthase inhibition; aldosterone synthase;
Aldosterone synthase inhibition: a novel bullet to fight cardiovascular-kidney metabolic syndrome.
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DOI: 10.1530/jme-25-0047
Abstract: Aldosterone is synthesized by the CYP11B2 enzyme, primarily in the zona glomerulosa of the adrenal gland. It exerts its classical effects on sodium and water balance in the renal distal nephron through binding to the… read more here.
Keywords: synthase inhibition; aldosterone synthase; inhibition novel; aldosterone ... See more keywords
Aldosterone synthase, polymorphism of its CYP11B2 gene in arterial hypertension and cardiovascular diseases associated with it (literature review)
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DOI: 10.22141/2224-1485.4.54.2017.109541
Abstract: The article presents the data of foreign and national literature on the pathogenetic role of aldosterone (AL), levels of aldosterone synthase (AS) and gene polymorphisms of this enzyme in patients with various forms of arterial… read more here.
Keywords: aldosterone synthase; arterial hypertension; pathology; hypertension ... See more keywords
The selective aldosterone synthase inhibitor Baxdrostat significantly lowers blood pressure in patients with resistant hypertension
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DOI: 10.3389/fendo.2022.1097968
Abstract: COPYRIGHT © 2022 Forzano, Mone, Varzideh, Jankauskas, Kansakar, De Luca and Santulli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in… read more here.
Keywords: aldosterone synthase; baxdrostat significantly; selective aldosterone; inhibitor baxdrostat ... See more keywords