Use of Steroid Profiling Combined With Machine Learning for Identification and Subtype Classification in Primary Aldosteronism
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2020.16209
Abstract: Key Points Question Does steroid profiling combined with machine learning offer a potential 1-step strategy to facilitate diagnosis and subtype classification for treatment stratification of patients with primary aldosteronism? Findings This diagnostic study involving patients… read more here.
Keywords: steroid profiling; aldosteronism; machine learning; profiling combined ... See more keywords
Refining the Definitions of Biochemical and Clinical Cure for Primary Aldosteronism Using the Primary Aldosteronism Surgical Outcome (PASO) Classification System
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DOI: 10.1007/s00268-017-4311-1
Abstract: IntroductionDetermination of outcomes after adrenalectomy for primary aldosteronism (PA) is limited by the lack of standardized definitions of cure. The Primary Aldosteronism Surgical Outcomes (PASO) group recently established new consensus definitions for biochemical and clinical… read more here.
Keywords: aldosteronism; primary aldosteronism; paso; biochemical clinical ... See more keywords
Screening for primary aldosteronism is underutilised in patients with chronic kidney disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Nephrology"
DOI: 10.1007/s40620-022-01267-3
Abstract: Primary aldosteronism (PA) is the most common and potentially curable endocrine cause of secondary hypertension, and carries a worse prognosis than essential hypertension. Despite the high prevalence of hypertension in patients with chronic kidney disease… read more here.
Keywords: primary aldosteronism; nephrology; aldosteronism; disease ... See more keywords
Primary Aldosteronism: JACC State-of-the-Art Review.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2019.09.057
Abstract: Primary aldosteronism (PA) is a common, but frequently overlooked, cause of arterial hypertension and excess cardiovascular events, particularly atrial fibrillation. As timely diagnosis and treatment can provide a cure of hyperaldosteronism and hypertension, even when… read more here.
Keywords: aldosteronism; art review; primary aldosteronism; aldosteronism jacc ... See more keywords
Suspected Borderline Aldosteronism in Hypertension: The Next Target?
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DOI: 10.1016/j.jacc.2020.05.071
Abstract: Xu et al. ([1][1]) investigated the actual frequency and clinical outcomes of primary aldosteronism (PA) in newly diagnosed hypertensive patients in China. At least 4% of patients were confirmed to have PA, whereas 7% including patients… read more here.
Keywords: aldosteronism; aldosteronism hypertension; hypertension next; borderline aldosteronism ... See more keywords
A Chinese pedigree with glucocorticoid remediable aldosteronism
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DOI: 10.1038/s41440-021-00685-3
Abstract: Glucocorticoid-remediable aldosteronism (GRA) is an autosomal-dominant inherited aldosteronism that is often accompanied by early-onset hypertension. GRA is caused by the unequal crossover of the 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) genes. As a result of… read more here.
Keywords: aldosteronism; aldosterone; gra; remediable aldosteronism ... See more keywords
Pathogenesis and treatment of primary aldosteronism
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Endocrinology"
DOI: 10.1038/s41574-020-0382-4
Abstract: Early diagnosis and appropriate treatment of primary aldosteronism, the most frequent cause of secondary hypertension, are crucial to prevent deleterious cardiovascular outcomes. In the past decade, the discovery of genetic abnormalities responsible for sporadic and… read more here.
Keywords: genetic abnormalities; aldosteronism; primary aldosteronism; treatment primary ... See more keywords
Are We Only Detecting the Tip of the Iceberg? A Nationwide Study on Primary Aldosteronism with up to 8-Year Follow-up
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine Research"
DOI: 10.1080/07435800.2022.2068572
Abstract: ABSTRACT Background Long-term follow-up studies on primary aldosteronism (PA) are lacking. Objective We aim to review results of diagnostic procedures and histopathology for patients diagnosed during 2012–2016 in Iceland, compare unilateral (UD) and bilateral disease… read more here.
Keywords: aldosteronism; tip iceberg; nationwide study; detecting tip ... See more keywords
Primary Aldosteronism: State-of-the-Art Review.
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DOI: 10.1093/ajh/hpac079
Abstract: We are witnessing a revolution in our understanding of primary aldosteronism. In the past two decades, we have learned that primary aldosteronism is a highly prevalent syndrome that is largely attributable to pathogenic somatic mutations,… read more here.
Keywords: art review; aldosteronism; state art; primary aldosteronism ... See more keywords
CONFIRMATORY AND SUBTYPE TESTING IN PATIENTS WITH SUSPECTED PRIMARY ALDOSTERONISM
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DOI: 10.1097/01.hjh.0000539503.49577.92
Abstract: Objective: Primary aldosteronism is one of the most common causes of secondary hypertension. Despite this, little information is available on routine clinical practice results of confirmatory and subtype testing in patients with suspected primary aldosteronism.… read more here.
Keywords: aldosteronism; patients suspected; primary aldosteronism; confirmatory subtype ... See more keywords
Case detection in primary aldosteronism: high-diagnostic value of the aldosterone-to-renin ratio when performed under standardized conditions
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000001718
Abstract: Objective: The aldosterone-to-renin ratio is widely used and is the recommended screening modality for primary aldosteronism by the Endocrine Society Guideline. However, studies on its diagnostic accuracy have been inconsistent, which is mainly because of… read more here.
Keywords: renin ratio; aldosterone renin; aldosteronism; primary aldosteronism ... See more keywords