Development and validation of a novel sensitive UV‐direct capillary electrophoresis method for quantification of alendronate in release studies from biomaterials
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DOI: 10.1002/elps.201700362
Abstract: A simple, highly sensitive, and robust CE method applied to the determination of alendronate (ALN) was developed from matrices for tissue engineering, characterized by being highly complex systems. The novel method was based on the… read more here.
Keywords: validation novel; development validation; alendronate; method ... See more keywords
Quantification of the bisphosphonate alendronate using capillary electrophoresis mass spectrometry with dynamic pH barrage junction focusing
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DOI: 10.1002/elps.202000228
Abstract: A quantitative method was developed for the direct identity confirmation and quantification of alendronate using CE‐MS combined with a pH‐assisted focusing technique, dynamic pH barrage junction focusing. A pH‐induced variation in electrophoretic mobility led to… read more here.
Keywords: quantification; junction focusing; alendronate; barrage junction ... See more keywords
Association of Alendronate and Risk of Cardiovascular Events in Patients With Hip Fracture
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DOI: 10.1002/jbmr.3448
Abstract: The risk of cardiovascular events (CVEs) with alendronate use in real‐world hip fracture patients is unknown. This study aimed to investigate the risk of CVE with and without use of alendronate in patients with hip… read more here.
Keywords: risk; alendronate; patients hip; risk cardiovascular ... See more keywords
Cost-effectiveness of denosumab versus oral alendronate for elderly osteoporotic women in Japan
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DOI: 10.1007/s00198-017-3940-4
Abstract: SummaryWe constructed a Markov microsimulation model among hypothetical cohorts of community-dwelling elderly osteoporotic Japanese women without prior hip or vertebral fractures over a lifetime horizon. Compared with weekly oral alendronate for 5 years, denosumab every 6 months… read more here.
Keywords: alendronate; denosumab; elderly osteoporotic; cost effectiveness ... See more keywords
Explanations for the difference in rates of cardiovascular events in a trial of alendronate and romosozumab
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DOI: 10.1007/s00198-020-05379-z
Abstract: Romosozumab, an anti-sclerostin antibody, has been approved for prescription in the USA, Europe, Japan, and South Korea to treat patients with osteoporosis who have a high risk of fracture. The Active-Controlled Fracture Study in Postmenopausal… read more here.
Keywords: difference; trial; probability; alendronate ... See more keywords
Are Bisphosphonates Associated with Adverse Metabolic and Cognitive Effects? A Study in Intact Rats and Rats Fed High-Fat High-Fructose Diet
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DOI: 10.1007/s00223-020-00684-5
Abstract: Osteocalcin, known as a bone gla protein, is considered a regulator of energy metabolism and behavior in its undercarboxylated form (ucOC). Antiresorptive drugs, such as alendronate, reduce serum level of ucOC. The purpose of the… read more here.
Keywords: alendronate; fructose diet; group; fat high ... See more keywords
Alendronate use and bone mineral density gains in women with moderate-severe (stages 3B–5) chronic kidney disease: an open cohort multivariable and propensity score analysis from Funen, Denmark
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DOI: 10.1007/s11657-020-00746-z
Abstract: Summary Bisphosphonates are contraindicated in moderate-to-severe chronic kidney disease patients. However, they are used to prevent fragility fractures in patients with impaired kidney function, despite a lack of evidence on their effects on bone density… read more here.
Keywords: chronic kidney; alendronate; density; moderate severe ... See more keywords
Long-term evaluation of alendronate treatment on the healing of calvaria bone defects in rats. Biochemical, histological and immunohistochemical analyses.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2020.104779
Abstract: OBJECTIVE The aim of this study was to investigate the effects of the long-term alendronate administration on bone healing in defects created in rat calvarias. MATERIALS AND METHODS Female Wistar rats were randomly distributed into… read more here.
Keywords: alendronate; long term; treatment; group ... See more keywords
Role of local alendronate delivery on the osseointegration of implants: a systematic review and meta-analysis.
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DOI: 10.1016/j.ijom.2017.03.009
Abstract: There is controversy regarding whether locally delivered alendronate enhances osseointegration. The aim of this systematic review was to assess the role of local alendronate delivery (topical, or as a coating on implant surfaces) in the… read more here.
Keywords: alendronate; systematic review; alendronate delivery; local alendronate ... See more keywords
Liposome‐induced immunosuppression and tumor growth is mediated by macrophages and mitigated by liposome‐encapsulated alendronate☆
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DOI: 10.1016/j.jconrel.2017.12.023
Abstract: ABSTRACT Liposomal nanoparticles are the most commonly used drug nano‐delivery platforms. However, recent reports show that certain pegylated liposomal nanoparticles (PLNs) and polymeric nanoparticles have the potential to enhance tumor growth and inhibit antitumor immunity… read more here.
Keywords: pln; tumor; alendronate; immunosuppression ... See more keywords
Open-label clinical trial of alendronate after teriparatide therapy in people with spinal cord injury and low bone mineral density
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DOI: 10.1038/s41393-019-0303-3
Abstract: Study designNon-randomized open-label clinical trial of oral alendronate after teriparatide therapy in people with spinal cord injury (SCI) and low bone mineral density (BMD).ObjectivesTo determine if alendronate would prevent bone loss after discontinuation of teriparatide.SettingOutpatient… read more here.
Keywords: bone mineral; alendronate; label clinical; bone ... See more keywords