Use of Structural Alerts for Reactive Metabolites in the Application SpotRM.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.4c00205
Abstract: Reactive metabolite (RM) formation is widely accepted as playing a crucial role in causing idiosyncratic adverse drug reactions (IADRs), where the liver is most affected. An important goal of drug design is to avoid selection… read more here.
Keywords: structural alerts; use structural; alerts reactive; drug ... See more keywords