α,α'-C-H Bond Difunctionalization of Unprotected Alicyclic Amines.
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DOI: 10.1021/acs.orglett.1c02187
Abstract: A simple one-pot procedure enables the sequential, regioselective, and diastereoselective introduction of the same or two different substituents to the α- and α'-positions of unprotected azacycles. Aryl, alkyl, and alkenyl substituents are introduced via their… read more here.
Keywords: difunctionalization unprotected; alicyclic amines; bond difunctionalization; unprotected alicyclic ... See more keywords
Regioselective α-Cyanation of Unprotected Alicyclic Amines.
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DOI: 10.1021/acs.orglett.2c02148
Abstract: Secondary alicyclic amines are converted to α-aminonitriles via addition of TMSCN to their corresponding imines, intermediates that are produced in situ via the oxidation of amine-derived lithium amides with simple ketone oxidants. Amines with an… read more here.
Keywords: unprotected alicyclic; cyanation; cyanation unprotected; regioselective cyanation ... See more keywords
Catalytic Lewis Base Additive Enables Selective Copper-Catalyzed Borylative α-C–H Allylation of Alicyclic Amines
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DOI: 10.1021/jacs.2c07969
Abstract: Functionalized alicyclic amines are important building blocks for the synthesis of bioactive natural compounds and drugs. Existing methods of functionalization are typically limited to the synthesis of protected amines or the use of highly basic… read more here.
Keywords: lewis base; base additive; copper catalyzed; catalytic lewis ... See more keywords
Sequential hydrogenation of nitroaromatics to alicyclic amines via highly-dispersed Ru–Pd nanoparticles anchored on air-exfoliated C3N4 nanosheets
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DOI: 10.1039/d2ra07612h
Abstract: Developing efficient and green catalytic systems is highly desired in the syntheses of alicyclic amines via hydrogenation of nitroaromatics. Herein, we developed Ru–Pd dual active site catalysts in which Ru and Pd species were anchored… read more here.
Keywords: amines via; highly dispersed; hydrogenation; hydrogenation nitroaromatics ... See more keywords