The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15205-z
Abstract: Cytokinesis requires the constriction of ESCRT-III filaments on the side of the midbody, where abscission occurs. After ESCRT recruitment at the midbody, it is not known how the ESCRT-III machinery localizes to the abscission site.… read more here.
Keywords: escrt iii; abscission site; alix; abscission ... See more keywords
Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis
Sign Up to like & getrecommendations! Published in 2019 at "Science Signaling"
DOI: 10.1126/scisignal.aaw3423
Abstract: Two independent trafficking pathways remove phosphorylated MLKL from the plasma membrane to avert necroptosis. Exit the necroptosis executioner In cells dying by necroptosis, the pseudokinase MLKL becomes phosphorylated and competent to rupture the plasma membrane.… read more here.
Keywords: flotillin; necroptosis; phosphorylated mlkl; membrane ... See more keywords