Efficacy and safety of ALK inhibitors in ALK-rearranged non-small cell lung cancer: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Lung cancer"
DOI: 10.1016/j.lungcan.2020.04.011
Abstract: OBJECTIVES No overall survival (OS) benefit has been reported from a mature randomized trial with the use of ALK inhibitors. We conducted a systematic review and meta-analysis to assess the efficacy of ALK inhibitors compared… read more here.
Keywords: alk inhibitors; alk alk; alk; meta analysis ... See more keywords
Exploring Alkyl-O-Alkyl Ether Structures in Softwood Milled Wood Lignins
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Agricultural and Food Chemistry"
DOI: 10.1021/acs.jafc.2c06375
Abstract: Recent studies have suggested that there are significant amounts of various alkyl ether (Alk-O-Alk; Alk = alkyl) moieties in a spruce native lignin preparation, milled wood lignin (SMWL). However, the comprehensive NMR assignment to these… read more here.
Keywords: lignin; milled wood; alk; alk alk ... See more keywords
有 ALK 组织病理学特征的斯皮茨痣样黑色素瘤基因重排显示 ALK 拷贝数增加: 导致斯皮茨痣样黑色素瘤中 ALK 激活的一种新机制
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Dermatology"
DOI: 10.1111/bjd.17493
Abstract: 斯皮茨痣样黑色素瘤是一种不常见的黑色素瘤(一类皮肤癌),可发生于任何年龄,看起来像一种名为“斯皮茨痣”的无害痣。这种相似性使其难以诊断。斯皮茨痣样瘤(斯皮茨痣)最近开始按照其基因特征进行分类,这意味着存在于其中的基因和某些分子改变与痣结构变化(可在显微镜下观察到)有关联。例如,斯皮茨痣样瘤具有一种叫做间变性淋巴瘤激酶 (ALK)的基因重排。ALK 这种基因指导身体合成有助于细胞彼此通讯的蛋白质。ALK 重排意味着该基因的一部分断裂并连接至另一基因。研究表明存在 ALK 重排的斯皮茨痣样瘤表现出不同的“丛状模式”。人体大多数基因都有两个拷贝,但有时分子改变会导致基因拷贝数增加或者一个拷贝丢失。如果增加了一个拷贝,则称之为拷贝数增加。在本报告中,来自美国的作者讨论了一个背部有一处 3 cm 肿瘤的 87 岁男性病例,并得出如下结论:ALK 拷贝数增加代表 ALK 在斯皮茨痣样瘤中激活的另一种机制,并显示出了与在 ALK重排的斯皮茨痣样瘤中观察到的相同丛状模式。 read more here.
Keywords: alk; dermatology; alk alk;