ALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via SERPINB4 expression
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2216479120
Abstract: Significance In this work, we have developed a highly controlled non-tumorigenic human bronchial epithelial cell system expressing four ALK fusions found in NSCLC. Employing RNA-seq and phosphoproteomics, we identify both common and isoform-specific differentially expressed… read more here.
Keywords: cell; expression; alk; alk fusions ... See more keywords
Unique genomic features in adolescent and young adult, as compared to older adult, non‐Hodgkin lymphoma and potential therapeutic targets
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.14157
Abstract: Non-Hodgkin lymphoma (NHL) can occur at any age, and is common in adolescents and young adults (AYA, age 15–39 years). The clinical outcome of AYA NHL can differ compared to younger and older populations. Treatment… read more here.
Keywords: genomic alterations; adult; age; alk fusions ... See more keywords
Molecular and clinical analysis of Chinese patients with anaplastic lymphoma kinase (ALK)‐rearranged non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Science"
DOI: 10.1111/cas.14177
Abstract: Anaplastic lymphoma kinase (ALK) fusions have been recognized as a therapeutic target in non‐small cell lung cancer (NSCLC). However, molecular signatures and clinical characteristics of the Chinese population with ALK‐rearranged NSCLC are not well elucidated.… read more here.
Keywords: lymphoma kinase; alk; alk fusions; anaplastic lymphoma ... See more keywords
Gene Mutation and Its Association with Clinicopathological Features in Young Patients with Non-Small-Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Emergency Medicine International"
DOI: 10.1155/2022/6333282
Abstract: Background We investigated the correlation between genetic mutations and clinical-pathological features in young patients with NSCLC. Methods Clinicopathologic information of 102 young NSCLC patients was collected. Direct ctDNA sequencing of a portion of these patients… read more here.
Keywords: features young; young patients; mutation; gene ... See more keywords
ALK Inhibitor Response in Melanomas Expressing EML4-ALK Fusions and Alternate ALK Isoforms
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-17-0472
Abstract: Oncogenic ALK fusions occur in several types of cancer and can be effectively treated with ALK inhibitors; however, ALK fusions and treatment response have not been characterized in malignant melanomas. Recently, a novel isoform of… read more here.
Keywords: alk inhibitors; melanomas; alk; response ... See more keywords
Characterization of Thyroid Cancer Driven by Known and Novel ALK Fusions.
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine-related cancer"
DOI: 10.1530/erc-19-0325
Abstract: ALK fusions are found in various tumors, including thyroid cancer, and serve as a diagnostic marker and therapeutic target. Spectrum and outcomes of ALK fusions found in thyroid nodules and cancer are not fully characterized.… read more here.
Keywords: alk; cancer; thyroid; alk fusions ... See more keywords
Complex ALK Fusions Are Associated With Better Prognosis in Advanced Non-Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.596937
Abstract: Background Echinoderm microtubule-associated protein-like 4 (EML4) is the canonical anaplastic lymphoma kinase (ALK) fusion partner in non-small cell lung cancer (NSCLC), and ALK-positive patients showed promising responses to ALK tyrosine kinase inhibitors (TKIs). However, studies… read more here.
Keywords: alk fusion; alk; alk fusions; non small ... See more keywords