ALK Gene Mutation and ALK Protein Expression in Advanced Neuroblastoma and the Potential Value in Risk Stratification in Fine-Needle Aspiration Biopsy Samples.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqac172
Abstract: OBJECTIVES The protein ALK is targeted for therapy in neuroblastoma, and ALK mutation confers a poor prognosis. We evaluated ALK in a cohort of patients with advanced neuroblastoma diagnosed by fine-needle aspiration biopsy (FNAB). METHODS… read more here.
Keywords: advanced neuroblastoma; expression; alk gene; mutation ... See more keywords
Dramatic response to crizotinib in a breast cancer patient with ALK gene rearrangement.
Sign Up to like & getrecommendations! Published in 2022 at "Anti-cancer drugs"
DOI: 10.1097/cad.0000000000001272
Abstract: Rearrangements of the anaplastic lymphoma kinase (ALK) gene are present in 3-5% of non-small-cell lung cancer (NSCLC), while it was 0.2% in NSCLC tumors. Due to its low frequency, it is extremely challenging to conduct… read more here.
Keywords: gene rearrangement; breast cancer; alk gene; alk ... See more keywords
Assessment of ALK gene rearrangement in lung cancer using a new rapid automated SureFISH (Dako Omnis) assay
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2016-204311
Abstract: The ALK fluorescence in situ hybridisation (FISH) method is the examination essential for pathological diagnosis and choice of molecular-targeted therapy in ALK-rearranged lung cancer. Here, for detection of ALK gene rearrangement in patients with lung… read more here.
Keywords: alk; gene rearrangement; dako omnis; lung cancer ... See more keywords
Detection of ALK Gene Rearrangement in Cell-free RNA from Lung Cancer Malignant Pleural Effusion
Sign Up to like & getrecommendations! Published in 2020 at "BioMed Research International"
DOI: 10.1155/2020/6124106
Abstract: The aim of this study was to evaluate the feasibility of measuring ALK gene rearrangement in cell-free RNA (cf-RNA) of the supernatant from malignant pleural effusion (MPE). Supernatant, cell blocks, and matched sera samples were… read more here.
Keywords: gene rearrangement; cell; rna; alk gene ... See more keywords
Construction of CTC-ALK gene fusion detection system based on the multi-site magnetic separation in lung cancer and its clinical verification.
Sign Up to like & getrecommendations! Published in 2020 at "Neoplasma"
DOI: 10.4149/neo_2020_200221n164
Abstract: Detected in a variety of solid tumors, including lung cancer, the EML4-ALK fusion gene plays an important role in promoting the occurrence and development of cancer. The existing detection methods for EML4-ALK fusion gene are… read more here.
Keywords: gene fusion; fusion; gene; alk gene ... See more keywords
Detection of ALK Gene Rearrangements in Non-Small Cell Lung Cancer by Immunocytochemistry and Fluorescence in Situ Hybridization on Cytologic Samples.
Sign Up to like & getrecommendations! Published in 2021 at "Turk patoloji dergisi"
DOI: 10.5146/tjpath.2021.01542
Abstract: OBJECTIVE Determination of the molecular status is mandatory for personalized treatment of patients with non-small cell lung carcinoma. The present study was performed to detect anaplastic lymphoma kinase (ALK) rearrangements in pulmonary adenocarcinoma on cytology… read more here.
Keywords: alk; detection alk; alk icc; cell ... See more keywords
A novel alkane monooxygenase (alkB) clade revealed by massive genomic survey and its dissemination association with IS elements
Sign Up to like & getrecommendations! Published in 2022 at "PeerJ"
DOI: 10.7717/peerj.14147
Abstract: Background Alkanes are important components of fossil energy, such as crude oil. The alkane monooxygenase encoded by alkB gene performs the initial step of alkane degradation under aerobic conditions. The alkB gene is well studied… read more here.
Keywords: alk genes; gene; alkane monooxygenase; alk gene ... See more keywords