Thrown for a Loop: Awakening BORIS to Evade ALK Inhibition Therapy.
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DOI: 10.1016/j.ccell.2019.09.009
Abstract: Mechanisms of acquired resistance to ALK inhibition therapy in neuroblastoma have not yet been elucidated. In a recent issue of Nature, Debruyne et al. demonstrate that resistant MYCN-amplified ALK-mutated neuroblastoma cells overexpress BORIS, resulting in wide-ranging… read more here.
Keywords: alk inhibition; thrown loop; inhibition therapy; alk ... See more keywords
Abstract 1007: SHP2 inhibition restores sensitivity to ALK inhibition in resistant ALK-rearranged non-small cell lung cancer (NSCLC)
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DOI: 10.1158/1538-7445.am2017-1007
Abstract: Despite development of highly potent and selective inhibitors (e.g., ceritinib, alectinib, lorlatinib) targeting anaplastic lymphoma kinase (ALK), resistance invariably develops and limits the efficacy of these inhibitors in the clinic. The major classes of resistance… read more here.
Keywords: bypass; alk; inhibition; cancer ... See more keywords