Primary ALK-negative anaplastic large cell lymphoma with extensive bone involvement mimicking multiple myeloma and metastatic carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Hematology"
DOI: 10.1007/s12185-019-02657-3
Abstract: A 68-year-old woman presented with a 4-month history of intense and diffuse bone pain, weight loss, and night sweats. Initially, the pain was localized in the right iliac and sacral region, but later it spread… read more here.
Keywords: negative anaplastic; bone; large cell; alk negative ... See more keywords
ALK-negative CNS anaplastic large cell lymphoma: case report and review of literature.
Sign Up to like & getrecommendations! Published in 2020 at "British journal of neurosurgery"
DOI: 10.1080/02688697.2020.1839630
Abstract: BACKGROUND Central nervous system (CNS) lymphomas frequently pose a diagnostic challenge to physicians. CNS anaplastic large cell lymphoma (ALCL) is a rare condition. A majority (80%) of ALCLs harbour anaplastic lymphoma kinase 1 (ALK-1) mutation… read more here.
Keywords: lymphoma; case; cns; large cell ... See more keywords
ALK-negative lung inflammatory myofibroblastic tumor in a young adult
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DOI: 10.1097/md.0000000000025972
Abstract: Supplemental Digital Content is available in the text Abstract Rationale: Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor that is prevalent among children and adolescents. Surgery is the most important therapeutic approach for IMT… read more here.
Keywords: alk negative; inflammatory myofibroblastic; lung; alk ... See more keywords
Clonal haematopoiesis of indeterminate potential among cancer survivors exposed to myelotoxic chemotherapy
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.15861
Abstract: genetic subtype. Fig S1. (A) Bacterial artificial chromosome (BACs) used for fluorescence in situ hybridization DUSP22 break-apart assays with hg 19 co-ordinates. (B) Partial karyotype showing the expected site of chromosomal localization (6p25.3) on normal… read more here.
Keywords: clonal haematopoiesis; negative neg; alk; break apart ... See more keywords
Anaplastic lymphoma kinase (ALK)‐negative anaplastic large cell lymphoma with MYC rearrangement
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.17169
Abstract: Anaplastic large-cell lymphoma (ALCL) can be further classified into anaplastic lymphoma kinase-positive (ALK) and ALK-negative types. ALK-negative ALCL is indistinguishable from ALK ALCL by morphology, but lacks ALK translocation or protein expression. Patients with ALK… read more here.
Keywords: lymphoma; cell; alk negative; negative alcl ... See more keywords
Indolent ALK‐negative anaplastic large‐cell lymphoma, DUSP22 rearranged, with an unusual immunophenotype in a human immunodeficiency virus patient
Sign Up to like & getrecommendations! Published in 2017 at "Histopathology"
DOI: 10.1111/his.13163
Abstract: The patient is a 54 year-old male with HIV diagnosed in 1992 who has been on HAART therapy with well controlled disease, no opportunistic infections, CD4 count >1000 cells / mm3 with an undetectable viral… read more here.
Keywords: negative anaplastic; large cell; alk negative; indolent alk ... See more keywords
Heterogeneity of tumor immune microenvironment of EGFR/ALK-positive tumors versus EGFR/ALK-negative tumors in resected brain metastases from lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-006243
Abstract: Background Previous studies found that lung adenocarcinomas (LUAD) with EGFR-positive and ALK-positive were less responsive to immunotherapy, which may be associated with a suppressive tumor immune microenvironment (TIME). Given the discordance in the TIME between… read more here.
Keywords: bms; egfr alk; alk negative; alk positive ... See more keywords
MYC Expression in Systemic Anaplastic Large Cell Lymphoma: Clinicopathologic and Prognostic Features of 70 Patients
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-124556
Abstract: Background: Dysregulation of MYC has oncogenic potential. It has been reported that MYC dysregulation (gene rearrangement, increased copy number, and protein overexpression) predicts poorer prognosis in patients with diffuse large B cell lymphoma. Systemic anaplastic… read more here.
Keywords: alcl; expression; alk negative; myc expression ... See more keywords
DUSP22 rearrangement is associated with a distinctive immunophenotype but not outcome in patients with systemic ALK-negative anaplastic large cell lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2022.281222
Abstract: DUSP22 rearrangement (R) has been associated with a favorable outcome in systemic ALK-negative anaplastic large cell lymphoma (ALCL). However, a recent study found that patients with DUSP22-R ALK-negative ALCL have a poorer prognosis than was… read more here.
Keywords: alk negative; rearrangement; alcl; patients dusp22 ... See more keywords
ALK-negative anaplastic large cell lymphoma with DUSP22 rearrangement has distinctive disease characteristics with better progression-free survival: a LYSA study
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2022.281442
Abstract: ALK-negative anaplastic large cell lymphoma (ALCL) comprises subgroups harboring rearrangements of DUSP22 (DUSP22-R) or TP63 (TP63-R). Two studies reported 90% and 40% 5-year overall survival (OS) rates in 21 and 12 DUSP22-R/TP63-not rearranged (NR) patients,… read more here.
Keywords: year; alk negative; dusp22; status ... See more keywords
ALK-1-negative anaplastic large-cell lymphoma presenting as a dura-based mass in an infant.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical neuropathology"
DOI: 10.5414/np301395
Abstract: INTRODUCTION Anaplastic large-cell lymphoma (ALCL) rarely occurs in the central nervous system in the pediatric population. CASE PRESENTATION We describe a diagnostically challenging case of an 11-month-old infant presenting with cranial nerve palsies and peripheral… read more here.
Keywords: alk negative; cell lymphoma; large cell; dura based ... See more keywords