Localized ALK-positive histiocytosis in a Chinese woman: report of a case in the lung with a novel EML4-ALK rearrangement
Sign Up to like & getrecommendations! Published in 2021 at "Virchows Archiv"
DOI: 10.1007/s00428-021-03092-8
Abstract: ALK-positive histiocytosis (APH) is a newly defined entity with specific histological features and a highly recurrent KIF5B-ALK gene fusion. APH is characterized by clonal proliferation of histiocytes and can present as either systemic or localized.… read more here.
Keywords: alk; alk rearrangement; alk positive; positive histiocytosis ... See more keywords
The effect of EML4-ALK break-apart ratio on crizotinib outcomes in non-small cell lung cancer harboring EML4-ALK rearrangement
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-021-03546-1
Abstract: Anaplastic lymphoma kinase (ALK) gene rearrangement exists in approximately 3–7% of non-small cell lung cancer (NSCLC) and more than 15% split or isolated red signals among 50 tumor nuclei scored in the FISH analysis defines… read more here.
Keywords: alk; alk rearrangement; break apart; alk positive ... See more keywords
Novel method for rapid fluorescence in-situ hybridization of ALK rearrangement using non-contact alternating current electric field mixing
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-15515-1
Abstract: Echinoderm microtubule-associated protein-like 4 gene and anaplastic lymphoma kinase gene (EML4-ALK) rearrangement is a key driver mutation in non-small cell lung cancer (NSCLC). Although Break-Apart ALK fluorescence in situ hybridization (FISH) is a reliable diagnostic… read more here.
Keywords: alk; alk rearrangement; fluorescence situ; method ... See more keywords
Pulmonary sarcomatoid carcinoma presenting both ALK rearrangement and PD-L1 high positivity
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000016754
Abstract: Abstract Rationale: Pulmonary sarcomatoid carcinoma (PSC) represents read more here.
Keywords: rearrangement high; treatment; sarcomatoid carcinoma; alk rearrangement ... See more keywords
Lung adenocarcinoma with EGFR 19Del and an ALK rearrangement benefits from alectinib instead of an EGFR-TKI: A case report
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030316
Abstract: Rationale: A remarkable concurrence of an EGFR mutation and an EML4-ALK fusion (double positive) occasionally occurs within a narrow number of patients. Previous studies using targeted therapy on EGFR/ALK co-mutated patients have commonly focused on… read more here.
Keywords: lung adenocarcinoma; alk rearrangement; alectinib instead; instead egfr ... See more keywords
Endometrial cancer with an EML4-ALK rearrangement
Sign Up to like & getrecommendations! Published in 2018 at "Cold Spring Harbor Molecular Case Studies"
DOI: 10.1101/mcs.a003020
Abstract: An 85-yr-old woman was diagnosed with endometrial adenocarcinoma, endometrioid type. Imaging studies showed a large tumor distending the endometrial canal without evidence of local invasion or extrauterine disease. A hysterectomy was performed, followed by microscopic… read more here.
Keywords: alk rearrangement; endometrial cancer; eml4; eml4 alk ... See more keywords
The prognostic implications of EGFR mutation and ALK rearrangement for the long‐term outcomes of patients with resected lung adenocarcinomas
Sign Up to like & getrecommendations! Published in 2019 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.13128
Abstract: To investigate the prognostic impact of epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) rearrangement for the overall survival (OS) of patients with surgically treated lung adenocarcinomas. read more here.
Keywords: alk rearrangement; egfr mutation; lung adenocarcinomas;
Identification of an EML4‐ALK rearrangement in an intrahepatic cholangiocarcinoma
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DOI: 10.1111/pin.13138
Abstract: To the Editor, Cholangiocarcinomas (CCA) consist in an heterogeneous group of cancers developed from biliary cells. According to their anatomical origin along the biliary tree, CCAs are classified into three distinct entities: intrahepatic CCAs (iCCA),… read more here.
Keywords: ccas; alk; alk rearrangement; cholangiocarcinoma ... See more keywords
Crizotinib in advanced non-small-cell lung cancer with concomitant ALK rearrangement and c-Met overexpression
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-5078-y
Abstract: ObjectiveCrizotinib can target against mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK), which has been considered as a multi-targeted tyrosine kinase inhibitor (TKI). The objective of this study was to explore the efficacy of crizotinib… read more here.
Keywords: overexpression; alk rearrangement; met overexpression; cancer ... See more keywords
PD-L1 expression and CD8+ tumor-infiltrating lymphocytes are associated with ALK rearrangement and clinicopathological features in inflammatory myofibroblastic tumors
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DOI: 10.18632/oncotarget.20948
Abstract: Background Inflammatory myofibroblastic tumors (IMTs) are rare mesenchymal neoplasms that are composed of myofibroblastic cells accompanied by inflammatory infiltrate. We investigated the immune profiles of IMTs, including PD-L1 expression and proportion of CD8+ tumor-infiltrating lymphocytes… read more here.
Keywords: alk; alk rearrangement; imts; expression ... See more keywords
ALK-rearrangement neuroendocrine carcinoma of the lung: a comprehensive study of a rare case series and review of literature
Sign Up to like & getrecommendations! Published in 2018 at "OncoTargets and therapy"
DOI: 10.2147/ott.s172124
Abstract: Driver mutations involving tyrosine kinase receptors play crucial roles in the oncogenesis of lung adenocarcinoma. However, receptor tyrosine kinase mutations are extremely rare events in primary pulmonary neuroendocrine carcinoma (NEC), which is a molecular heterogeneous… read more here.
Keywords: alk rearrangement; case series; study; case ... See more keywords