Detection of ALK rearrangements in 4002 Russian patients: The utility of different diagnostic approaches.
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DOI: 10.1016/j.lungcan.2016.11.001
Abstract: BACKGROUND Clinical guidelines highly recommended the detection of potentially targetable genetic aberrations such as anaplastic lymphoma kinase (ALK) rearrangements in patients with non-small cell lung cancer (NSCLC). Few methods, such as the ALK break apart… read more here.
Keywords: detection; alk; ihc fish; russian patients ... See more keywords
Are all ALK rearrangements created equal
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DOI: 10.21037/12615
Abstract: The discovery of ALK rearrangements in non-small cell lung cancer (NSCLC) and their oncogenic properties by Soda et al . in 2007 gave the start to one of the most famous stories in the treatment… read more here.
Keywords: alk; rearrangements created; alk rearrangements; cancer ... See more keywords
Targeting ALK Rearrangements in NSCLC: Current State of the Art
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DOI: 10.3389/fonc.2022.863461
Abstract: Anaplastic lymphoma kinase (ALK) alterations in non-small cell lung cancer (NSCLC) can be effectively treated with a variety of ALK-targeted drugs. After the approval of the first-generation ALK inhibitor crizotinib which achieved better results in… read more here.
Keywords: alk inhibitors; generation alk; alk rearrangements; targeting alk ... See more keywords
Identification of Targetable ALK Rearrangements in Pancreatic Ductal Adenocarcinoma.
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DOI: 10.6004/jnccn.2017.0058
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a 5-year survival of 8%. Current therapeutic regimens are largely ineffective and underscore the need for novel treatment strategies. Chromosomal rearrangements involving the… read more here.
Keywords: ductal adenocarcinoma; alk; exon alk; pancreatic ductal ... See more keywords