ALK1 regulates the internalization of endoglin and the type III TGF-β receptor
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e20-03-0199
Abstract: Complex formation and endocytosis of transforming growth factor-β (TGF-β) receptors play important roles in signaling. However, their interdependence remained unexplored. Here, we demonstrate that ALK1, a TGF-β type I receptor prevalent in endothelial cells, forms… read more here.
Keywords: tgf; endocytosis; alk1; tgf receptor ... See more keywords
An update on preclinical models of hereditary haemorrhagic telangiectasia: Insights into disease mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.973964
Abstract: Endoglin (ENG) is expressed on the surface of endothelial cells (ECs) where it efficiently binds circulating BMP9 and BMP10 ligands to initiate activin A receptor like type 1 (ALK1) protein signalling to protect the vascular… read more here.
Keywords: hereditary haemorrhagic; disease; alk1; preclinical models ... See more keywords
Endothelial Activin Receptor-Like Kinase 1 (ALK1) Regulates Myofibroblast Emergence and Peritubular Capillary Stability in the Early Stages of Kidney Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.843732
Abstract: Renal tubulo-interstitial fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) in the tubular interstitium during chronic kidney disease. The main source of ECM proteins are emerging and proliferating myofibroblasts. The sources of… read more here.
Keywords: kidney fibrosis; receptor like; activin receptor; alk1 ... See more keywords
The ALK1-Smad1/5-ID1 pathway participates in tumour angiogenesis induced by low-dose photodynamic therapy
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Oncology"
DOI: 10.3892/ijo.2023.5503
Abstract: Photodynamic therapy (PDT) is an effective and low-invasive tumour therapy. However, it can induce tumour angiogenesis, which is a main factor leading to tumour recurrence and metastasis. Activin receptor-like kinase-1 (ALK1) is a key factor… read more here.
Keywords: tumour angiogenesis; dose pdt; alk1; angiogenesis ... See more keywords