Kaempferol 3‐O‐gentiobioside, an ALK5 inhibitor, affects the proliferation, migration, and invasion of tumor cells via blockade of the TGF‐β/ALK5/Smad signaling pathway
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DOI: 10.1002/ptr.7278
Abstract: Overactivation of TGF‐β/ALK5/Smad signaling pathway has been observed in the advanced stage of various human malignancies. As a key component of TGF‐β/ALK5/Smad signaling pathway transduction, TGF‐β type I receptor (also known as ALK5) has emerged… read more here.
Keywords: alk5; tgf alk5; smad signaling; signaling pathway ... See more keywords
TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking
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DOI: 10.1038/s41467-020-15404-8
Abstract: Transforming growth factor beta (TGFβ) is a multipotent immunosuppressive cytokine. TGFβ excludes immune cells from tumors, and TGFβ inhibition improves the efficacy of cytotoxic and immune therapies. Using preclinical colorectal cancer models in cell type-conditional… read more here.
Keywords: cxcr3; cd8; alk5; cd8 cells ... See more keywords
BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5
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DOI: 10.1371/journal.pone.0177188
Abstract: Selection and maturation of B cells into plasma cells producing high-affinity antibodies occur in germinal centers (GC). GCs form transiently in secondary lymphoid organs upon antigen challenge, and the GC reaction is a highly regulated… read more here.
Keywords: bmp; alk5; effect; receptor type ... See more keywords
Inhibitors of Activin Receptor-like Kinase 5 Interfere with SARS-CoV-2 S-Protein Processing and Spike-Mediated Cell Fusion via Attenuation of Furin Expression
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DOI: 10.3390/v14061308
Abstract: Screening of a protein kinase inhibitor library identified SB431542, targeting activin receptor-like kinase 5 (ALK5), as a compound interfering with SARS-CoV-2 replication. Since ALK5 is implicated in transforming growth factor β (TGF-β) signaling and regulation… read more here.
Keywords: cell; kinase; expression; alk5 ... See more keywords