L’expression d’ALK7 dans le prolactinome est associée à une réduction de la prolactine et à une prolifération accrue
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DOI: 10.1016/j.ando.2018.06.378
Abstract: Les prolactinomes representent les tumeurs hypophysaires hormonodependantes les plus frequentes. Elles sont souvent benigne mais peuvent devenir agressives/envahissantes via des mecanismes inconnus. La decouverte de marqueurs est donc essentielle pour developper de nouvelles strategies diagnostiques/pronostiques.… read more here.
Keywords: prolactine; alk7; alk7 est; expression alk7 ... See more keywords
Non-canonical ALK7 pathways promote pancreatic cancer metastasis through β-catenin/MMP-mediated basement membrane breakdown and intravasation
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DOI: 10.1186/s12943-025-02384-w
Abstract: Breaching the vascular barrier is a critical step in pancreatic ductal adenocarcinoma (PDAC) metastasis, yet the mechanisms enabling this process remain incompletely understood. Transforming growth factor beta (TGFβ) receptors have been extensively studied in many… read more here.
Keywords: cancer; alk7; catenin; breakdown intravasation ... See more keywords
1937-P: ALK-7: A Validated Target for the Treatment of Obesity
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DOI: 10.2337/db20-1937-p
Abstract: Genetic variation in the ACVR1C gene has been reported to be associated with decreased waist-to-hip ratio and risk of type 2 diabetes in humans. However, the effect of this naturally occurring variation on ALK7 function… read more here.
Keywords: alk7; obesity; self acceleron; target ... See more keywords