Long term observation of ocular surface alkali burn in rabbit models: Quantitative analysis of corneal haze, vascularity and self-recovery.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental eye research"
DOI: 10.1016/j.exer.2021.108526
Abstract: Limbal Stem Cell Deficiency (LSCD), caused due to corneal injury, primarily by chemical/alkali burns, leads to compromised vision. Recently, several animal models of corneal alkali burn injury have become available. The majority of the studies… read more here.
Keywords: corneal; surface; alkali burn; alkali ... See more keywords
Comparison of therapeutic effects between topical 8-oxo-2′-deoxyguanosine and corticosteroid in ocular alkali burn model
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-86440-7
Abstract: We compared the therapeutic effects of topical 8-oxo-2′-deoxyguanosine (8-oxo-dG) and corticosteroid in a murine ocular alkali burn model. (n = 128) The corneal alkali burn model was established by applying 0.1 N sodium hydroxide (NaOH), followed by… read more here.
Keywords: ocular alkali; alkali burn; therapeutic effects; burn model ... See more keywords
Dexamethasone and MicroRNA-204 Inhibit Corneal Neovascularization.
Sign Up to like & getrecommendations! Published in 2022 at "Military medicine"
DOI: 10.1093/milmed/usac260
Abstract: INTRODUCTION This was an in vivo animal study designed to investigate the interaction between dexamethasone (Dex) and microRNA-204 (miR-204) in a mouse alkali burn-induced corneal neovascularization (CNV) model. The function of miR-204 was then investigated… read more here.
Keywords: dex; mir 204; microrna 204; alkali burn ... See more keywords
Subconjunctival administration of mesenchymal stem cells alleviates ocular inflammation in a murine model of corneal alkali burn.
Sign Up to like & getrecommendations! Published in 2023 at "Stem cells"
DOI: 10.1093/stmcls/sxad027
Abstract: Corneal alkali burns cause extensive damage not only on the cornea but also into the intraocular tissues. As an anti-inflammatory therapy, subconjunctival administration of mesenchymal stem cells (MSCs) for corneal protection after corneal alkali burn… read more here.
Keywords: burn; subconjunctival administration; corneal alkali; mscs ... See more keywords
Alkali Burn Over a LASIK Flap.
Sign Up to like & getrecommendations! Published in 2020 at "Cornea"
DOI: 10.1097/ico.0000000000002604
Abstract: PURPOSE To describe the management and outcome of an ocular surface alkali burn in the setting of previous laser in situ keratomileusis (LASIK). METHODS This is a case report and review of relevant literature. RESULTS… read more here.
Keywords: lasik flap; lasik; burn lasik; alkali burn ... See more keywords
The Wound Healing Effect of Doxycycline after Corneal Alkali Burn in Rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Ophthalmology"
DOI: 10.1155/2019/5168652
Abstract: Purpose To evaluate the wound healing effect of doxycycline and its underlying mechanisms in a rat model of corneal alkali burn. Methods Male SD rats were administered 1.0 N NaOH in the right cornea for 25… read more here.
Keywords: wound healing; corneal alkali; group; alkali burn ... See more keywords
Effect of nintedanib thermo-sensitive hydrogel on neovascularization in alkali burn rat model.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2020.06.04
Abstract: AIM To investigate the effects of nintedanib thermo-sensitive hydrogel (NTH) on neovascularization and related markers in corneal alkali burns of Wistar rats. METHODS NTH was prepared by grinding, and its phase-transition temperature was determined. Thirty… read more here.
Keywords: group; model; neovascularization; alkali burn ... See more keywords
Topical Ophthalmic Formulation of Trichostatin A and SurR9-C84A for Quick Recovery Post-alkali Burn of Corneal Haze
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00223
Abstract: Alkali burn injury is a true ocular emergency of the conjunctiva and cornea that requires immediate precision. Lack of an immediate therapy can lead to a substantial damage in the ocular surface and anterior segment… read more here.
Keywords: surr9 c84a; alkali burn; surr9; tsa surr9 ... See more keywords
Extracellular Matrix Deposition and Remodeling after Corneal Alkali Burn in Mice
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22115708
Abstract: Corneal transparency relies on the precise arrangement and orientation of collagen fibrils, made of mostly Type I and V collagen fibrils and proteoglycans (PGs). PGs are essential for correct collagen fibrillogenesis and maintaining corneal homeostasis.… read more here.
Keywords: matrix deposition; sulfate; extracellular matrix; alkali burn ... See more keywords
Effect of Tauroursodeoxycholic Acid on Inflammation after Ocular Alkali Burn
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911717
Abstract: Inflammation is the main cause of corneal and retinal damage in an ocular alkali burn (OAB). The aim of this study was to investigate the effect of tauroursodeoxycholic acid (TUDCA) on ocular inflammation in a… read more here.
Keywords: inflammation; tauroursodeoxycholic acid; effect tauroursodeoxycholic; ocular alkali ... See more keywords
Topical Pirfenidone-Loaded Liposomes Ophthalmic Formulation Reduces Haze Development after Corneal Alkali Burn in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14020316
Abstract: Corneal chemical burns (CCBs) frequently result in corneal fibrosis or haze, an opacity of the cornea that obstructs vision and induces corneal blindness. Diverse strategies have been employed to prevent or reduce CCB-related corneal haze.… read more here.
Keywords: formulation; corneal alkali; topical pirfenidone; corneal ... See more keywords