A Modular Synthesis of the Rhazinilam Family of Alkaloids and Analogs Thereof.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02446
Abstract: A short, modular strategy for synthesizing three representative alkaloids of the (±)-rhazinilam family and 10 non-natural analogs is described. The protocol involves a radical addition/cyclization cascade reaction that assembles the tetrahydroindolizine system decorated with appropriate… read more here.
Keywords: family; alkaloids analogs; rhazinilam family; family alkaloids ... See more keywords
Enantioselective Synthesis of Isocarbostyril Alkaloids and Analogs Using Catalytic Dearomative Functionalization of Benzene.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b12123
Abstract: Enantioselective total syntheses of the anticancer isocarbostyril alkaloids (+)-7-deoxypancratistatin, (+)-pancratistatin, (+)-lycoricidine, and (+)-narciclasine are described. Our strategy for accessing this unique class of natural products is based on the development of a Ni-catalyzed dearomative trans-1,2-carboamination… read more here.
Keywords: isocarbostyril alkaloids; natural products; alkaloids analogs; benzene ... See more keywords