Biomimetic Total Syntheses of Ergot Alkaloids via Decarboxylative Giese Coupling.
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DOI: 10.1021/acs.orglett.0c03867
Abstract: Biomimetic total syntheses of Festuclavine and Pyroclavine were achieved by a sequential radical coupling. The key steps include intramolecular decarboxylative Giese reaction to form the central C ring and 4-nitrobenzenesulfonyl (Ns)-directed indole C4-H olefination to… read more here.
Keywords: total syntheses; biomimetic total; alkaloids via; decarboxylative giese ... See more keywords
Total Synthesis of Indolizidine Alkaloids via Nickel-Catalyzed (4 + 2) Cyclization.
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DOI: 10.1021/acs.orglett.9b04479
Abstract: A Ni-catalyzed (4 + 2) cycloaddition of alkynes and azetidinones toward piperidinones was used as key reaction in the enantioselective synthesis of naturally occurring indolizidine alkaloids. The reaction benefits from the use of an easily… read more here.
Keywords: synthesis indolizidine; total synthesis; alkaloids via; indolizidine alkaloids ... See more keywords