Selective Inhibitors of AlkB Family of Nucleic Acid Demethylases.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00774
Abstract: The α-ketoglutarate-dependent (AlkB) superfamily of FeII/2-oxoglutarate (2-OG) -dependent dioxygenases consists of a unique class of nucleic acid repair enzymes which reversibly remove alkyl substituents from nucleobases through oxidative dealkylation. Recent studies have verified the involvement… read more here.
Keywords: family nucleic; alkb family; inhibitors alkb; selective inhibitors ... See more keywords
The bioinformatics and experimental analysis of AlkB family for prognosis and immune cell infiltration in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "PeerJ"
DOI: 10.7717/peerj.12123
Abstract: Background Serving as N6-methyladenosine demethylases, the AlkB family is involved in the tumorigenesis of hepatocellular carcinoma (HCC). However, the molecular profiles and clinical values of the AlkB family in HCC are not well known. Methods… read more here.
Keywords: hepatocellular carcinoma; immune cell; hcc; alkb family ... See more keywords