LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "alkbh1" as a keyword



Demethyltransferase AlkBH1 substrate diversity and relationship to human diseases.

Sign Up to like & get
recommendations! Published in 2021 at "Molecular biology reports"

DOI: 10.1007/s11033-021-06421-x

Abstract: AlkBH1 is a member of the AlkB superfamily which are kinds of Fe (II) and α-ketoglutarate (α-KG)-dependent dioxygenases. At present, only demethyltransferases FTO and AlkBH5 have relatively clear substrate studies among these members, the types… read more here.

Keywords: alkbh1; diversity; alkbh1 substrate; substrate diversity ... See more keywords
Photo by nci from unsplash

Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA

Sign Up to like & get
recommendations! Published in 2020 at "Cell Research"

DOI: 10.1038/s41422-019-0237-5

Abstract: N6-methyladenine (N6-mA) of DNA is an emerging epigenetic mark in mammalian genome. Levels of N6-mA undergo drastic fluctuation during early embryogenesis, indicative of active regulation. Here we show that the 2-oxoglutarate-dependent oxygenase ALKBH1 functions as… read more here.

Keywords: alkbh1; alkbh1 serves; unpairing regions; dna ... See more keywords
Photo by nci from unsplash

ALKBH1 contributes to renal cell carcinoma progression by reducing N6-methyladenine of GPR137.

Sign Up to like & get
recommendations! Published in 2023 at "European journal of clinical investigation"

DOI: 10.1111/eci.13986

Abstract: Renal cell carcinoma (RCC) accounts for approximately 4% of all the adult malignancies with the high mortality worldwide. Although conventional chemotherapy and radiotherapy treatment has been applied for RCC in clinic, the mortality rate of… read more here.

Keywords: cell; gpr137; cell carcinoma; renal cell ... See more keywords
Photo by nci from unsplash

Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans

Sign Up to like & get
recommendations! Published in 2019 at "Journal of Cell Science"

DOI: 10.1242/jcs.223891

Abstract: ABSTRACT The Fe(II) and 2-oxoglutarate-dependent oxygenase Alkb homologue 1 (Alkbh1) has been shown to act on a wide range of substrates, like DNA, tRNA and histones. Thereby different enzymatic activities have been identified including, among… read more here.

Keywords: alkbh1; mitochondrial upr; knockdown induces; microscopy ... See more keywords