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   Articles with "alkbh5" as a keyword



ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202507254

Abstract: The overexpression of ALKBH5 alleviates damage to cardiomyocytes and tissues, decreases the expression of SLC7A11, and inhibits the expression of p53N/T and ferroptosis. ALKBH5 induces ferroptosis in the HH/R model by mutating the 3′‐UTR of… read more here.

Keywords: alkbh5; 142 173; p53; g3bp1 ... See more keywords

ALKBH5 modulates bone cancer pain in a rat model by suppressing NR2B expression

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recommendations! Published in 2024 at "Biotechnology and Applied Biochemistry"

DOI: 10.1002/bab.2601

Abstract: Currently, the clinical treatment of bone cancer pain (BCP) is mainly related to its pathogenesis. The aim of the present study was to elucidate the potential role of N6‐methyladenosine (m6A) in BCP in the spinal… read more here.

Keywords: bone cancer; alkbh5; rat model; expression ... See more keywords

ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1

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recommendations! Published in 2019 at "Journal of Physiology and Biochemistry"

DOI: 10.1007/s13105-019-00690-8

Abstract: N6-Methyladenosine (m6A) is the most common posttranscriptional modification of RNA and plays critical roles in cancer pathogenesis. However, the biological function of long noncoding RNA (lncRNA) methylation remains unclear. As a demethylase, ALKBH5 (alkylation repair… read more here.

Keywords: gastric cancer; alkbh5; methylation; invasion metastasis ... See more keywords

m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.

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recommendations! Published in 2017 at "Cancer cell"

DOI: 10.1016/j.ccell.2017.02.013

Abstract: The dynamic and reversible N6-methyladenosine (m6A) RNA modification installed and erased by N6-methyltransferases and demethylases regulates gene expression and cell fate. We show that the m6A demethylase ALKBH5 is highly expressed in glioblastoma stem-like cells… read more here.

Keywords: foxm1; expression cell; glioblastoma; alkbh5 ... See more keywords
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Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis.

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recommendations! Published in 2020 at "Cell stem cell"

DOI: 10.1016/j.stem.2020.04.001

Abstract: N6-methyladenosine (m6A) is a commonly present modification of mammalian mRNAs and plays key roles in various cellular processes. m6A modifiers catalyze this reversible modification. However, the underlying mechanisms by which these m6A modifiers are regulated… read more here.

Keywords: m6a modifiers; alkbh5; leukemia stem; stem ... See more keywords

Decreased ALKBH5 in neutrophil correlates with disease activity in rheumatoid arthritis and ALKBH5 modulates neutrophil autophagy

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-21727-7

Abstract: Neutrophils are key immune components in rheumatoid arthritis (RA), but the role of ALKBH5 in neutrophil function and RA progression remains unclear. METTL3, METTL14, WTAP, ALKBH5, FTO, YTHDF2, autophagy related gene were investigated by RT-qPCR.… read more here.

Keywords: disease activity; alkbh5; rheumatoid arthritis; neutrophil autophagy ... See more keywords

ALKBH5 ALLEVIATES HYPOXIA POSTCONDITIONING INJURY IN d-GALACTOSE–INDUCED SENESCENT CARDIOMYOCYTES BY REGULATING STAT3

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recommendations! Published in 2023 at "Shock"

DOI: 10.1097/shk.0000000000002031

Abstract: ABSTRACT Ischemic postconditioning (I/Post) reduces I/R injury by activating endogenous cardioprotection mechanisms, such as the JAK/signal transducer and activator of transcription 3 (STAT3) and PI3K/Akt pathways, which offer a traditional approach to myocardial protection. According… read more here.

Keywords: senescent cardiomyocytes; alkbh5; stat3; m6a ... See more keywords

RNA demethylase ALKBH5 promotes ovarian carcinogenesis in a simulated tumour microenvironment through stimulating NF‐κB pathway

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recommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.15228

Abstract: Methylation is the main form of RNA modification. N6‐methyladenine (m6A) regulates the splicing and translation of mRNA. Alk B homologue 5 (ALKBH5) participates in the biological regulation of various cancers. However, its role in ovarian… read more here.

Keywords: alkbh5; expression; ovarian cancer; ovarian carcinogenesis ... See more keywords

Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling.

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recommendations! Published in 2025 at "Science"

DOI: 10.1126/science.adp4120

Abstract: Maintaining glucose and lipid homeostasis is crucial for health, with dysregulation leading to metabolic diseases such as type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated fatty liver disease (MAFLD). This study identifies alkylation repair homolog… read more here.

Keywords: glucose lipid; alkbh5; mtorc1 signaling; lipid homeostasis ... See more keywords

The DEAD-Box RNA Helicase DDX3 Interacts with m6A RNA Demethylase ALKBH5

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recommendations! Published in 2017 at "Stem Cells International"

DOI: 10.1155/2017/8596135

Abstract: DDX3 is a member of the family of DEAD-box RNA helicases. DDX3 is a multifaceted helicase and plays essential roles in key biological processes such as cell cycle, stress response, apoptosis, and RNA metabolism. In… read more here.

Keywords: alkbh5; ddx3; rna; dead box ... See more keywords

Abstract 3528: ALKBH5 promotes cancer growth by regulating ER homeostasis via UPR, autophagy, and mitochondrial function

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-3528

Abstract: Background: N6-methyladenosine (m6A) RNA methylation is a dynamic reversible epitranscriptomic modification that includes methyl transferases (writes m6A), demethylases (erases m6A) and reader proteins, which proofreads m6A marks of a specific site of transcripts. Recent studies… read more here.

Keywords: growth regulating; cancer; alkbh5; microscopy ... See more keywords