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   Articles with "alkbh5" as a keyword



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ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1

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recommendations! Published in 2019 at "Journal of Physiology and Biochemistry"

DOI: 10.1007/s13105-019-00690-8

Abstract: N6-Methyladenosine (m6A) is the most common posttranscriptional modification of RNA and plays critical roles in cancer pathogenesis. However, the biological function of long noncoding RNA (lncRNA) methylation remains unclear. As a demethylase, ALKBH5 (alkylation repair… read more here.

Keywords: gastric cancer; alkbh5; methylation; invasion metastasis ... See more keywords
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m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.

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recommendations! Published in 2017 at "Cancer cell"

DOI: 10.1016/j.ccell.2017.02.013

Abstract: The dynamic and reversible N6-methyladenosine (m6A) RNA modification installed and erased by N6-methyltransferases and demethylases regulates gene expression and cell fate. We show that the m6A demethylase ALKBH5 is highly expressed in glioblastoma stem-like cells… read more here.

Keywords: foxm1; expression cell; glioblastoma; alkbh5 ... See more keywords
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Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis.

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recommendations! Published in 2020 at "Cell stem cell"

DOI: 10.1016/j.stem.2020.04.001

Abstract: N6-methyladenosine (m6A) is a commonly present modification of mammalian mRNAs and plays key roles in various cellular processes. m6A modifiers catalyze this reversible modification. However, the underlying mechanisms by which these m6A modifiers are regulated… read more here.

Keywords: m6a modifiers; alkbh5; leukemia stem; stem ... See more keywords

ALKBH5 ALLEVIATES HYPOXIA POSTCONDITIONING INJURY IN d-GALACTOSE–INDUCED SENESCENT CARDIOMYOCYTES BY REGULATING STAT3

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recommendations! Published in 2023 at "Shock"

DOI: 10.1097/shk.0000000000002031

Abstract: ABSTRACT Ischemic postconditioning (I/Post) reduces I/R injury by activating endogenous cardioprotection mechanisms, such as the JAK/signal transducer and activator of transcription 3 (STAT3) and PI3K/Akt pathways, which offer a traditional approach to myocardial protection. According… read more here.

Keywords: senescent cardiomyocytes; alkbh5; stat3; m6a ... See more keywords
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RNA demethylase ALKBH5 promotes ovarian carcinogenesis in a simulated tumour microenvironment through stimulating NF‐κB pathway

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recommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.15228

Abstract: Methylation is the main form of RNA modification. N6‐methyladenine (m6A) regulates the splicing and translation of mRNA. Alk B homologue 5 (ALKBH5) participates in the biological regulation of various cancers. However, its role in ovarian… read more here.

Keywords: alkbh5; expression; ovarian cancer; ovarian carcinogenesis ... See more keywords
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The DEAD-Box RNA Helicase DDX3 Interacts with m6A RNA Demethylase ALKBH5

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recommendations! Published in 2017 at "Stem Cells International"

DOI: 10.1155/2017/8596135

Abstract: DDX3 is a member of the family of DEAD-box RNA helicases. DDX3 is a multifaceted helicase and plays essential roles in key biological processes such as cell cycle, stress response, apoptosis, and RNA metabolism. In… read more here.

Keywords: alkbh5; ddx3; rna; dead box ... See more keywords
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Abstract 3528: ALKBH5 promotes cancer growth by regulating ER homeostasis via UPR, autophagy, and mitochondrial function

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-3528

Abstract: Background: N6-methyladenosine (m6A) RNA methylation is a dynamic reversible epitranscriptomic modification that includes methyl transferases (writes m6A), demethylases (erases m6A) and reader proteins, which proofreads m6A marks of a specific site of transcripts. Recent studies… read more here.

Keywords: growth regulating; cancer; alkbh5; microscopy ... See more keywords
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ALKBH5 Functions As an Oncogene in Acute Myeloid Leukemia

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recommendations! Published in 2018 at "Blood"

DOI: 10.1182/blood-2018-99-118988

Abstract: N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic messenger RNAs (mRNAs) has been shown to play important roles in diverse cellular and pathological processes (Deng X, et al. Cell Res. 2018;28:507-517). ALKBH5, recently identified… read more here.

Keywords: alkbh5; myeloid leukemia; acute myeloid; aml ... See more keywords
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Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification

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recommendations! Published in 2022 at "Molecular Cancer"

DOI: 10.1186/s12943-022-01522-y

Abstract: Background Gastric cancer (GC) is one of the most pernicious tumors that seriously harm human healthcare. GC metastasis is one of the prime cause of failed cancer treatment, but correlation between N6-methyladenosine (m6A) and GC… read more here.

Keywords: cancer; alkbh5; metastasis; m6a ... See more keywords
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ALKBH5 Regulates SPHK1-Dependent Endothelial Cell Angiogenesis Following Ischemic Stress

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recommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"

DOI: 10.3389/fcvm.2021.817304

Abstract: Background Endothelial cells dysfunction has been reported in many heart diseases including acute myocardial infarction, and atherosclerosis. The molecular mechanism for endothelial dysfunction in the heart is still not clearly understood. We aimed to study… read more here.

Keywords: alkbh5; angiogenesis; ischemic stress; ecs angiogenesis ... See more keywords

miRNA-193a-3p Regulates the AKT2 Pathway to Inhibit the Growth and Promote the Apoptosis of Glioma Cells by Targeting ALKBH5

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recommendations! Published in 2021 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2021.600451

Abstract: Emerging evidence indicates that microRNA (miR)-193a-3p is involved in the tumor progression of various cancers. However, the biological functions and precise molecular mechanisms of miR-193a-3p in gliomas have not been well documented. Accordingly, this study… read more here.

Keywords: glioma; apoptosis; alkbh5; mir 193a ... See more keywords