Intramolecular Azide–Alkene Cycloaddition—The Logothetis Reaction
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500472
Abstract: The assembly of cyclic amines is fundamental to medicinal chemistry. While intramolecular azide–alkyne cycloaddition is widely practiced, intramolecular azide–alkene cycloaddition is much less used, even though it has been known since 1965. This review is… read more here.
Keywords: chemistry; alkene cycloaddition; intramolecular azide; azide alkene ... See more keywords
Bridged-Type Selective Intramolecular Nitrone-Alkene Cycloaddition: Computational Chemistry-Inspired Regioselectivity Control.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c00125
Abstract: A regioselective intramolecular nitrone-alkene cycloaddition for synthesizing oxazabicyclo ring-fused indoles is reported. Computational studies guided the development of optimal conditions using In(OTf)3 as a Lewis acidic reagent. This method demonstrates a broad substrate scope, forming… read more here.
Keywords: intramolecular nitrone; chemistry; alkene cycloaddition; nitrone alkene ... See more keywords