Bridgehead Alkene-Enabled Strain-Driven Bioorthogonal Reaction.
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DOI: 10.1021/acs.orglett.2c01895
Abstract: Herein, we report a novel bioorthogonal reaction that hinges on a bridgehead alkene (BHA)-enabled inverse-electron-demand Diels-Alder (IEDDA) cycloaddition. Readily accessible from natural product β-caryophyllene, the strained BHA displays high reactivity toward the IEDDA reaction while… read more here.
Keywords: alkene enabled; bioorthogonal reaction; reaction; strain driven ... See more keywords