Copper-Catalyzed Difluoroalkylation of Alkene/Nitrile Insertion/Cyclization Tandem Sequences: Construction of Difluorinated Bicyclic Amidines.
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DOI: 10.1021/acs.orglett.1c03802
Abstract: A copper-catalyzed difluoroalkylation of an alkene/nitrile insertion/cyclization tandem sequence of N-cyanamide alkene was described, which provided a convenient synthetic approach for accessing difluorinated bicyclic amidines bearing imine moieties in a sustainable fashion. This protocol is… read more here.
Keywords: alkene; copper catalyzed; catalyzed difluoroalkylation; alkene nitrile ... See more keywords