Selective Hydrofunctionalization of Alkenyl Fluorides Enabled by Nickel-Catalyzed Hydrogen Atoms and Group Transfer: Reaction Development and Mechanistic Study.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c01506
Abstract: Due to the unique effect of fluorine atoms, the efficient construction of high-value alkyl fluorides has attracted significant interest in modern drug development. However, enantioselective catalytic strategies for the efficient assembly of highly functionalized chiral… read more here.
Keywords: reaction; development; alkenyl fluorides; nickel catalyzed ... See more keywords
Stereodefined alkenes with a fluoro-chloro terminus as a uniquely enabling compound class
Sign Up to like & getrecommendations! Published in 2022 at "Nature Chemistry"
DOI: 10.1038/s41557-022-00893-5
Abstract: Trisubstituted alkenyl fluorides are important compounds for drug discovery, agrochemical development and materials science. Despite notable progress, however, many stereochemically defined trisubstituted fluoroalkenes either cannot be prepared efficiently or can only be accessed in one… read more here.
Keywords: alkenyl fluorides; trisubstituted alkenyl; compound; chloro terminus ... See more keywords