Catalytic Asymmetric Decarboxylative Michael Addition To Construct an All-Carbon Quaternary Center with 3-Alkenyl-oxindoles.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00411
Abstract: The first highly enantioselective asymmetric decarboxylative addition of β-keto acids with 3-alkenyl-oxindoles bearing an all-carbon quaternary stereocenter have been developed. The relevant products were acquired in 49-98% yields with 88-98% enantioselectivities in the presence of… read more here.
Keywords: addition; carbon quaternary; asymmetric decarboxylative; alkenyl oxindoles ... See more keywords
B(C6F5)3-catalyzed cyclopropanation of 3-alkenyl-oxindoles with diazomethanes.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc06744g
Abstract: Spirocyclopropane-oxindoles are key motifs in biologically active compounds and are versatile synthetic intermediates. Herein, we report a metal-free, B(C6F5)3 catalyzed cyclopropanation of 3-alkenyl-oxindoles with diazomethanes. This provides 25 variants of spirocyclopropane-oxindole derivatives. These spirocyclopropane-oxindole products… read more here.
Keywords: cyclopropanation alkenyl; catalyzed cyclopropanation; alkenyl oxindoles; c6f5 catalyzed ... See more keywords