Rhodium-Catalyzed C-H Alkenylation/Electrocyclization Cascade Provides Dihydropyridines That Serve as Versatile Intermediates to Diverse Nitrogen Heterocycles.
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DOI: 10.1021/acs.accounts.1c00027
Abstract: ConspectusNitrogen heterocycles are present in approximately 60% of drugs, with nonplanar heterocycles incorporating stereogenic centers being of considerable interest to the fields of medicinal chemistry, chemical biology, and synthetic methods development. Over the past several… read more here.
Keywords: alkenylation electrocyclization; nitrogen heterocycles; electrocyclization cascade; versatile intermediates ... See more keywords