A powerful approach to alkoxy radical-mediated remote C(sp3)–H bonds functionalization
Sign Up to like & getrecommendations! Published in 2018 at "Science China Chemistry"
DOI: 10.1007/s11426-018-9222-6
Abstract: The activation of inert C(sp)–H bonds with control of reactivity and selectivity is one of the central topics in chemical sciences. In this context, alkoxy radical-mediated 1,5hydrogen atom transfer allows the regioselective transformation of inert… read more here.
Keywords: powerful approach; alkoxy radicals; bond; chemistry ... See more keywords
Alkoxy Radicals See the Light: New Paradigms of Photochemical Synthesis.
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DOI: 10.1021/acs.chemrev.1c00256
Abstract: Alkoxy radicals are highly reactive species that have long been recognized as versatile intermediates in organic synthesis. However, their development has long been impeded due to a lack of convenient methods for their generation. Thanks… read more here.
Keywords: alkoxy radicals; radicals see; generation; alkoxy radical ... See more keywords
Alcohol Etherification via Alkoxy Radicals Generated by Visible-Light Photoredox Catalysis
Sign Up to like & getrecommendations! Published in 2020 at "Organic Letters"
DOI: 10.1021/acs.orglett.0c03058
Abstract: A mechanistically divergent method is described that, employing a commercially available hypervalent iodine(III) reagent, generates alkoxy radicals from 1°, 2°, and 3° alcohols and allows their use in the functionalization of C(sp3)–H and C(sp2)–H bonds.… read more here.
Keywords: alkoxy radicals; photoredox catalysis; light photoredox; visible light ... See more keywords
Manganese-Catalyzed Electrochemical Deconstructive Chlorination of Cycloalkanols via Alkoxy Radicals
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DOI: 10.1021/acs.orglett.9b03652
Abstract: A manganese-catalyzed electrochemical deconstructive chlorination of cycloalkanols has been developed. This electrochemical method provides access to alkoxy radicals from alcohols and exhibits a broad substrate scope, with various cyclopropanols and cyclobutanols converted into synthetically useful… read more here.
Keywords: alkoxy radicals; deconstructive chlorination; manganese catalyzed; catalyzed electrochemical ... See more keywords
Identification of Alkoxy Radicals as Hydrogen Atom Transfer Agents in Ce-Catalyzed C-H Functionalization.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10126
Abstract: The intermediacy of alkoxy radicals in cerium-catalyzed C-H functionalization via H-atom abstraction has been unambiguously confirmed. Catalytically relevant Ce(IV)-alkoxide complexes have been synthesized and characterized by X-ray diffraction. Operando electron paramagnetic resonance and transient absorption… read more here.
Keywords: hydrogen atom; transfer; alkoxy radicals; atom transfer ... See more keywords
Catalytic generation of alkoxy radicals from unfunctionalized alcohols
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DOI: 10.1039/d0sc04542j
Abstract: This review summarizes recent advances in the catalytic generation of alkoxy radicals from unfunctionalized alcohols and highlights current methods for O–H bond activation. read more here.
Keywords: catalytic generation; generation alkoxy; alkoxy radicals; unfunctionalized alcohols ... See more keywords