Photoredox-Catalyzed Allylic Defluorinative Alkoxycarbonylation of Trifluoromethyl Alkenes through Intermolecular Alkoxycarbonyl Radical Addition.
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DOI: 10.1021/acs.orglett.1c04359
Abstract: The gem-difluoroalkene moiety is an ideal carbonyl bioisostere in medicinal chemistry, but efficient synthesis of β-gem-difluoroalkene esters remains challenging so far. Herein, we disclose a photoredox-catalyzed allylic defluorinative alkoxycarbonylation of trifluoromethyl alkenes enabled by intermolecular… read more here.
Keywords: allylic defluorinative; defluorinative alkoxycarbonylation; alkoxycarbonylation trifluoromethyl; catalyzed allylic ... See more keywords