Catalytic Access to 4-(sec-Alkyl)Anilines via 1,6-Conjugate Addition of Grignard Reagents to in Situ Generated aza-p-Quinone Methides
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DOI: 10.1021/acs.orglett.2c02786
Abstract: The synthesis of aniline derivatives, common building blocks in many pharmaceuticals, agrochemicals, dyes or polymers, has been limited to reactions based on benzene-toluene-xylene derivatives (BTX) due to their ample availability. Despite the large number of… read more here.
Keywords: addition grignard; grignard reagents; alkyl anilines; aza quinone ... See more keywords
Brønsted acid-catalyzed metal- and solvent-free quinoline synthesis from N-alkyl anilines and alkynes or alkenes
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DOI: 10.1039/c7gc03175k
Abstract: Bronsted acid-catalyzed cyclization reactions of N-alkyl anilines with alkynes or alkenes in the presence of oxygen gas as an oxidant under metal- and solvent-free conditions are described. Various quinoline derivatives are obtained in satisfactory to… read more here.
Keywords: alkynes alkenes; alkyl anilines; metal solvent; acid catalyzed ... See more keywords